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Query: NC_008258:3224721:3234291 Shigella flexneri 5 str. 8401, complete genome

Start: 3234291, End: 3234830, Length: 540

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011748:3608917:362143036214303621969540Escherichia coli 55989, complete genomehypothetical protein1e-101368
CU928145:3608917:362143036214303621969540Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein1e-101368
NC_011415:3523364:353585635358563536416561Escherichia coli SE11 chromosome, complete genomehypothetical protein6e-101365
CP002185:3475991:348555834855583486097540Escherichia coli W, complete genomehypothetical protein6e-101365
CP002516:613462:619976619976620515540Escherichia coli KO11, complete genomehypothetical protein6e-101365
NC_016902:613462:619976619976620515540Escherichia coli KO11FL chromosome, complete genomehypothetical protein6e-101365
NC_002695:3994970:400746240074624008022561Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein6e-101365
NC_013941:3884725:389721738972173897777561Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein6e-101365
NC_011741:3344746:335431533543153354854540Escherichia coli IAI1 chromosome, complete genomehypothetical protein2e-100364
CU928160:3344746:335431533543153354854540Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein2e-100364
NC_009800:3307123:331667133166713317231561Escherichia coli HS, complete genomehypothetical protein4e-100363
NC_009801:3595001:360271036027103603270561Escherichia coli E24377A, complete genomehypothetical protein4e-100363
NC_011750:3768692:378120537812053781744540Escherichia coli IAI39 chromosome, complete genomehypothetical protein4e-100363
NC_011751:3710786:372330037233003723839540Escherichia coli UMN026 chromosome, complete genomehypothetical protein4e-100363
NC_010498:3488513:349808234980823498621540Escherichia coli SMS-3-5, complete genomehypothetical protein9e-100362
AC_000091:3258377:326770932677093268248540Escherichia coli W3110 DNA, complete genomehypothetical protein8e-100362
NC_010468:613812:622167622167622706540Escherichia coli ATCC 8739, complete genomehypothetical protein8e-100362
NC_000913:3256307:326587632658763266415540Escherichia coli K12, complete genomehypothetical protein8e-100362
NC_010473:3354052:336362133636213364160540Escherichia coli str. K-12 substr. DH10B, complete genomehypothetical protein8e-100362
NC_012759:3143455:315302431530243153563540Escherichia coli BW2952 chromosome, complete genomehypothetical protein8e-100362
NC_012947:630757:639112639112639651540Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein8e-100362
NC_012967:3191319:320088832008883201427540Escherichia coli B str. REL606 chromosome, complete genomehypothetical protein8e-100362
NC_004741:3240909:325071432507143251016303Shigella flexneri 2a str. 2457T, complete genome1e-54212