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Query: NC_008258:269806:293591 Shigella flexneri 5 str. 8401, complete genome

Start: 293591, End: 293821, Length: 231

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011740:2072173:210463921046392104818180Escherichia fergusonii ATCC 35469, complete genomeconserved hypothetical protein from phage origin2e-25114
NC_017328:303987:322559322559322729171Shigella flexneri 2002017 chromosome, complete genomeGp647e-2095.9
NC_016860:364981:384481384481384657177Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein3e-26116
NC_006511:2501500:251135125113512511527177Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein1e-26118
NC_011147:2496808:250688725068872507063177Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein1e-26118
NC_011083:374000:390698390698390874177Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,hypothetical protein2e-25114
NC_009800:289000:306457306457306633177Escherichia coli HS, complete genomehypothetical protein9e-27118
NC_013941:975353:993220993220993432213Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeNinF protein3e-1994
NC_011601:1039500:105667910566791056849171Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeprotein NinF3e-21100
NC_011601:717072:735687735687735866180Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeprotein NinF5e-0959.7
NC_013364:2645438:264657426465742646744171Escherichia coli O111:H- str. 11128, complete genomeputative NinF protein2e-1994.4