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Query: NC_008258:269806:290308 Shigella flexneri 5 str. 8401, complete genome

Start: 290308, End: 291132, Length: 825

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:303987:319215319215320105891Shigella flexneri 2002017 chromosome, complete genomeO protein2e-146518
NC_011147:2496808:251062225106222511521900Salmonella enterica subsp. enterica serovar Paratyphi A strDNA replication2e-114412
NC_006511:2501500:251508625150862515985900Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCDNA replication2e-114412
NC_010067:2529750:258565725856572586556900Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-113409
NC_009778:2993218:301459530145953015491897Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein5e-102370
NC_013850:1887556:190154319015431902436894Klebsiella variicola At-22 chromosome, complete genomereplication protein O6e-101367
NC_009800:289000:302940302940303839900Escherichia coli HS, complete genomeputative replication protein O2e-94345
NC_013364:2645438:265048526504852651384900Escherichia coli O111:H- str. 11128, complete genomeputative replication protein2e-93342
NC_021066:2226826:224259322425932243426834Raoultella ornithinolytica B6, complete genomehypothetical protein9e-70263
NC_016845:1285435:129611212961121296963852Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,hypothetical protein4e-64244
NC_014306:3524980:356534435653443566291948Erwinia billingiae Eb661, complete genomePhage replication protein O3e-21102
NC_015566:3659318:3659318365931836604151098Serratia sp. AS12 chromosome, complete genomephage O protein family5e-1685.1
NC_017338:2034698:206725420672542068147894Staphylococcus aureus subsp. aureus JKD6159 chromosome, completehypothetical protein5e-0858.5
NC_002758:2101137:211312421131242114017894Staphylococcus aureus subsp. aureus Mu50, complete genomehypothetical protein5e-0858.5
NC_002745:2018761:203592520359252036818894Staphylococcus aureus subsp. aureus N315, complete genomehypothetical protein5e-0858.5
NC_010079:2102856:211527621152762116169894Staphylococcus aureus subsp. aureus USA300_TCH1516, completepossible DNA replication protein DnaD5e-0858.5
NC_009487:2148316:215821721582172159110894Staphylococcus aureus subsp. aureus JH9 chromosome, completeprimosome subunit DnaD5e-0858.5
NC_009487:362475:372003372003372896894Staphylococcus aureus subsp. aureus JH9 chromosome, completeprimosome subunit DnaD5e-0858.5
NC_009632:2148767:215809121580912158984894Staphylococcus aureus subsp. aureus JH1 chromosome, completeprimosome subunit DnaD5e-0858.5
NC_009632:361229:372073372073372966894Staphylococcus aureus subsp. aureus JH1 chromosome, completeprimosome subunit DnaD5e-0858.5
NC_017343:1963912:198107419810741981967894Staphylococcus aureus subsp. aureus ECT-R 2, complete genomednaD and phage-associated domain protein5e-0858.5
NC_017351:2074000:210098121009812101874894Staphylococcus aureus subsp. aureus 11819-97 chromosome, completednaD domain protein5e-0858.5
NC_009641:2101579:211896021189602119844885Staphylococcus aureus subsp. aureus str. Newman chromosome,phage regulatory protein6e-0651.6