Pre_GI: BLASTP Hits

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Query: NC_008258:269806:281566 Shigella flexneri 5 str. 8401, complete genome

Start: 281566, End: 281922, Length: 357

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007946:2625461:263531026353102635846537Escherichia coli UTI89, complete genomehypothetical protein2e-56216
NC_013361:3287671:330093633009363301523588Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein1e-37154
NC_011083:374000:380699380699381316618Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,Gp375e-36149
NC_016860:364981:371911371911372420510Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein1e-29128
NC_013361:1558423:156453915645391565168630Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein8e-1889
NC_011601:1039500:104623110462311046794564Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein3e-1477.4
NC_011205:609464:621303621303621884582Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853Eae protein2e-1271.2
NC_011094:593100:604550604550605047498Salmonella enterica subsp. enterica serovar Schwarzengrund strEae protein2e-1270.9
NC_010067:2529750:259384825938482594354507Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-1269.7
NC_020063:2565605:258034225803422580722381Enterobacteriaceae bacterium strain FGI 57, complete genomehypothetical protein6e-1269.7
NC_012759:2342986:235933823593382359700363Escherichia coli BW2952 chromosome, complete genomeCPS-53 (KpLE1) prophage protein9e-1268.9
NC_000913:2455037:247353324735332473895363Escherichia coli K12, complete genomeCPS-53 (KpLE1) prophage; predicted protein9e-1268.9
NC_010473:2548946:256529825652982565660363Escherichia coli str. K-12 substr. DH10B, complete genomeCPS-53 (KpLE1) prophage; predicted protein9e-1268.9
AC_000091:2462461:248095724809572481319363Escherichia coli W3110 DNA, complete genomehypothetical protein9e-1268.9
NC_015968:3301958:331721033172103318001792Enterobacter asburiae LF7a chromosome, complete genomehypothetical protein4e-1063.2