Pre_GI: BLASTP Hits

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Query: NC_008258:269806:279662 Shigella flexneri 5 str. 8401, complete genome

Start: 279662, End: 280501, Length: 840

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013353:2911741:291747429174742918427954Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein7e-64243
AP010958:2911741:291747429174742918427954Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein7e-64243
NC_013008:3231414:324556332455633246069507Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeheme binding virulence factor2e-42172
NC_011353:3276734:329069232906923291198507Escherichia coli O157:H7 str. EC4115 chromosome, complete genomebacteriophage protein2e-42172
NC_009800:289000:293833293833294474642Escherichia coli HS, complete genomehypothetical protein9e-37154
NC_017328:303987:312617312617313291675Shigella flexneri 2002017 chromosome, complete genomeputative bacteriophage protein9e-34144
NC_006905:368942:3749463749463761211176Salmonella enterica subsp. enterica serovar Choleraesuis strEaa protein2e-1066.6
NC_013361:3287671:330299633029963303583588Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein3e-1065.9
NC_016860:364981:371050371050371841792Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein1e-0963.9
NC_007946:2625461:263614426361442636716573Escherichia coli UTI89, complete genomehypothetical protein1e-0963.5
NC_013353:5361207:536761653676165367996381Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein6e-0961.6
AP010958:5361207:536761653676165367996381Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein6e-0961.6
NC_013364:1596278:161111016111101611463354Escherichia coli O111:H- str. 11128, complete genomehypothetical protein2e-0859.7
NC_010067:2304313:232186323218632322444582Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-0858.5
NC_013361:3287671:330238233023823302999618Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein6e-0858.2
NC_011601:2614691:262797926279792628374396Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein1e-0757.4
NC_011601:717072:723556723556723951396Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein1e-0757.4
NC_013361:1558423:156185315618531562764912Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein1e-0757.4
NC_011353:3276734:329188632918863292503618Escherichia coli O157:H7 str. EC4115 chromosome, complete genome3e-0755.8
NC_013008:3231414:324675732467573247374618Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehypothetical protein3e-0755.8
NC_002655:1332961:133323813332381333861624Escherichia coli O157:H7 EDL933, complete genomeunknown protein encoded by bacteriophage BP-933W3e-0755.8
NC_013941:3300000:330934033093403309843504Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeValyl-tRNA synthetase1e-0653.9
NC_013361:3651150:365492736549273655790864Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein1e-0653.9
NC_013353:5361207:536799353679935368811819Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein1e-0653.9
AP010958:5361207:536799353679935368811819Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein1e-0653.9
NC_011205:609464:6195466195466206281083Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853Eaa protein2e-0653.1