Pre_GI: BLASTP Hits

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Query: NC_008258:269806:271433 Shigella flexneri 5 str. 8401, complete genome

Start: 271433, End: 271858, Length: 426

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011750:2928990:294167329416732942101429Escherichia coli IAI39 chromosome, complete genomeputative tail protein4e-76282
NC_011740:621408:623032623032623460429Escherichia fergusonii ATCC 35469, complete genomeputative tail protein4e-76282
NC_011742:2823000:284218628421862842614429Escherichia coli S88 chromosome, complete genometail protein1e-74278
NC_008563:2909945:292487629248762925304429Escherichia coli APEC O1, complete genomebacteriophage V tail protein1e-74278
NC_007946:2894793:290984929098492910274426Escherichia coli UTI89, complete genomebacteriophage V tail protein1e-74277
NC_009436:2776410:279160927916092792034426Enterobacter sp. 638, complete genomephage GP46 family protein7e-63238
NC_010102:1779707:180386118038611804274414Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein5e-39159
NC_011094:2115750:213125821312582131671414Salmonella enterica subsp. enterica serovar Schwarzengrund strphage protein GP465e-39159
NC_011205:2137696:215260021526002153013414Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853phage protein GP465e-39159
NC_011294:2009388:202429320242932024706414Salmonella enterica subsp. enterica serovar Enteritidis strphage protein5e-39159
NC_016810:2027311:204557620455762045989414Salmonella enterica subsp. enterica serovar Typhimurium strbacteriophage protein5e-39159
NC_016856:2085283:209941320994132099826414Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Shypothetical protein5e-39159
NC_016857:2027311:204557620455762045989414Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74putative tail protein5e-39159
NC_016863:2029340:204760520476052048018414Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1hypothetical protein5e-39159
NC_017046:2026672:204493720449372045350414Salmonella enterica subsp. enterica serovar Typhimurium str. 798bacteriophage protein5e-39159
NC_007712:1182518:119620711962071196617411Sodalis glossinidius str. 'morsitans', complete genomehypothetical protein6e-31132
NC_002947:4362271:438552343855234385909387Pseudomonas putida KT2440, complete genomephage FluMu protein gp462e-1684.7
NC_002937:255790:257565257565258041477Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completetail protein, putative2e-1064.7
NC_014228:3282500:331080433108043311253450Xenorhabdus nematophila ATCC 19061, complete genomeputative bacteriophage protein2e-1064.7
NC_002937:2933000:295284429528442953320477Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completetail protein, putative2e-1064.3
NC_009800:2049346:207167220716722072121450Escherichia coli HS, complete genomephage protein GP461e-0961.6
NC_000907:1568867:158883415888341589241408Haemophilus influenzae Rd KW20, complete genomehypothetical protein6e-0959.7
NC_015733:1398083:139858013985801398966387Pseudomonas putida S16 chromosome, complete genomephage FluMu protein gp468e-0959.3