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Query: NC_008258:269806:269806 Shigella flexneri 5 str. 8401, complete genome

Start: 269806, End: 270885, Length: 1080

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011205:2137696:2153544215354421546081065Salmonella enterica subsp. enterica serovar Dublin str. CT_020218538e-122437
NC_009436:2776410:2792576279257627936551080Enterobacter sp. 638, complete genomebacteriophage Mu P family protein1e-171602
NC_011094:2115750:2132209213220921332671059Salmonella enterica subsp. enterica serovar Schwarzengrund strbacteriophage Mu P protein5e-130464
NC_009800:2049346:2072696207269620737811086Escherichia coli HS, complete genomebacteriophage Mu P protein3e-35149
NC_017046:2026672:2045888204588820469461059Salmonella enterica subsp. enterica serovar Typhimurium str. 798bacteriophage tail protein1e-129463
NC_016810:2027311:2046527204652720475851059Salmonella enterica subsp. enterica serovar Typhimurium strbacteriophage tail protein1e-129463
NC_007946:2894793:2910822291082229119011080Escherichia coli UTI89, complete genomebacteriophage V tail protein0694
NC_010102:1779707:1804812180481218058701059Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-129462
NC_016863:2029340:2048556204855620496141059Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1hypothetical protein4e-129461
NC_012751:1071589:107158910715891072230642Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum), completeMu-like phage P protein7e-61234
NC_016628:373815:394080394080395018939Vibrio furnissii NCTC 11218 chromosome 2, complete sequencephage tail protein2e-0653.5
NC_011294:2009388:2025244202524420263021059Salmonella enterica subsp. enterica serovar Enteritidis strphage tail protein5e-130464
NC_002947:4362271:4386415438641543875241110Pseudomonas putida KT2440, complete genomephage tail protein, putative2e-68259
NC_002927:3827211:3839659383965938407621104Bordetella bronchiseptica RB50, complete genomeputative phage tail protein1e-1171.2
NC_012721:2694829:2719548271954827207171170Burkholderia glumae BGR1 chromosome 2, complete genomePutative tail protein6e-31135
NC_008563:2909945:2925849292584929269281080Escherichia coli APEC O1, complete genomeputative tail protein0694
NC_014228:3282500:3309177330917733102651089Xenorhabdus nematophila ATCC 19061, complete genomeputative tail protein5e-28125
NC_011742:2823000:2843159284315928442381080Escherichia coli S88 chromosome, complete genomeTail protein0694
NC_011750:2928990:2942646294264629437251080Escherichia coli IAI39 chromosome, complete genometail protein0688
NC_011740:621408:6214086214086224871080Escherichia fergusonii ATCC 35469, complete genomeTail protein0690
NC_016856:2085283:2100364210036421014221059Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Stail protein1e-129463
NC_016857:2027311:2046527204652720475851059Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74Tail protein1e-129463
NC_002937:2933000:2953962295396229550951134Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completetail protein, putative5e-38158
NC_002937:255790:2557902557902569231134Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completetail protein, putative6e-39161