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Query: NC_008258:269806:268481 Shigella flexneri 5 str. 8401, complete genome

Start: 268481, End: 269809, Length: 1329

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007946:2894793:2911898291189829132531356Escherichia coli UTI89, complete genomebacteriophage V tail/DNA circulation protein0862
NC_009436:2776410:2793652279365227949681317Enterobacter sp. 638, complete genomeDNA circulation family protein0655
NC_011740:621408:6200836200836214111329Escherichia fergusonii ATCC 35469, complete genomeTail/DNA circulation protein0859
NC_011750:2928990:2943722294372229450921371Escherichia coli IAI39 chromosome, complete genometail/DNA circulation protein0859
NC_008563:2909945:2926925292692529282951371Escherichia coli APEC O1, complete genomebacteriophage V tail/DNA circulation protein0861
NC_011742:2823000:2844235284423528456051371Escherichia coli S88 chromosome, complete genomeTail/DNA circulation protein0861
NC_010102:1779707:1805867180586718072071341Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein7e-128457
NC_011205:2137696:2154605215460521559451341Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853tail/DNA circulation protein9e-128457
NC_016810:2027311:2047582204758220489221341Salmonella enterica subsp. enterica serovar Typhimurium strbacteriophage protein9e-128457
NC_016856:2085283:2101419210141921027591341Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Shypothetical protein9e-128457
NC_016857:2027311:2047582204758220489221341Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74tail/DNA circulation protein9e-128457
NC_016863:2029340:2049611204961120509511341Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1hypothetical protein9e-128457
NC_017046:2026672:2046943204694320482831341Salmonella enterica subsp. enterica serovar Typhimurium str. 798bacteriophage protein9e-128457
NC_011294:2009388:2026299202629920276391341Salmonella enterica subsp. enterica serovar Enteritidis strhypothetical protein2e-127456
NC_011094:2115750:2133264213326421346041341Salmonella enterica subsp. enterica serovar Schwarzengrund strtail/DNA circulation protein3e-127455
NC_007712:1182518:1198296119829611996211326Sodalis glossinidius str. 'morsitans', complete genomephage tail/DNA circulation protein6e-123441
NC_000907:1568867:1585613158561315869801368Haemophilus influenzae Rd KW20, complete genome64 kDa virion protein5e-30132
NC_002937:2933000:2955218295521829564171200Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completetail/DNA circulation protein, putative1e-25117
NC_012751:899394:9096879096879109881302Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum), completeMu-like prophage DNA circulation protein6e-23108
NC_014228:3282500:3307784330778433091841401Xenorhabdus nematophila ATCC 19061, complete genomeputative DNA circulation protein9e-1892
NC_012721:2694829:2718174271817427195441371Burkholderia glumae BGR1 chromosome 2, complete genomeDNA circulation-like protein3e-1790.1
NC_008014:112000:1291051291051303701266Lawsonia intracellularis PHE/MN1-00 plasmid 3, complete sequencehypothetical protein2e-1377
NC_002927:3827211:3840746384074638420051260Bordetella bronchiseptica RB50, complete genomehypothetical protein3e-1273.6
NC_017243:1734179:1734179173417917354291251Brachyspira intermedia PWS/A chromosome, complete genomeDNA circulation family protein4e-0963.2