Pre_GI: BLASTP Hits

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Query: NC_008258:2542863:2551730 Shigella flexneri 5 str. 8401, complete genome

Start: 2551730, End: 2552215, Length: 486

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:2586171:259489125948912595376486Shigella flexneri 2002017 chromosome, complete genomehypothetical protein4e-92336
NC_004337:2548288:255752625575262557738213Shigella flexneri 2a str. 301, complete genomehypothetical protein9e-36149
NC_004741:2526421:253565925356592535871213Shigella flexneri 2a str. 2457T, complete genomehypothetical protein9e-36149
NC_006570:1794832:1807573180757318089191347Francisella tularensis subsp. tularensis Schu 4, complete genomeglutamate decarboxylase3e-32137
NC_008245:1794629:1807370180737018087161347Francisella tularensis subsp. tularensis FSC 198, complete genomeglutamate decarboxylase3e-32137
NC_016933:1870558:1883299188329918846451347Francisella tularensis TIGB03 chromosome, complete genomeGlutamate decarboxylase3e-32137
NC_016937:1794651:1807392180739218087381347Francisella tularensis subsp. tularensis TI0902 chromosome,glutamate decarboxylase3e-32137
NC_009257:78291:8558585585869311347Francisella tularensis subsp. tularensis WY96-3418 chromosome,glutamate decarboxylase3e-32137
NC_008601:1811327:1822118182211818234641347Francisella tularensis subsp. novicida U112, complete genomeglutamate decarboxylase3e-32137
NC_007880:1780702:1793853179385317949741122Francisella tularensis subsp. holarctica, complete genomeglutamate decarboxylase1e-31135
NC_005071:523423:5262825262825277211440Prochlorococcus marinus str. MIT 9313, complete genomeGlutamate decarboxylase1e-30132
NC_015224:3892972:3909568390956839109681401Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,glutamate decarboxylase8e-30129
NC_011740:1595381:1613670161367016150701401Escherichia fergusonii ATCC 35469, complete genomeglutamate decarboxylase B, PLP-dependent2e-29128
NC_011740:2859933:2883597288359728849971401Escherichia fergusonii ATCC 35469, complete genomeglutamate decarboxylase A, PLP-dependent3e-29127
NC_008800:4013298:4032296403229640336961401Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,glutamate decarboxylase2e-29127
NC_004431:1754627:1756318175631817577871470Escherichia coli CFT073, complete genomeGlutamate decarboxylase beta4e-29126
NC_007613:1533024:1554856155485615562561401Shigella boydii Sb227, complete genomeglutamate decarboxylase isozyme1e-28125
NC_002695:2091890:2091890209189020932901401Escherichia coli O157:H7 str. Sakai, complete genomeglutamate decarboxylase isozyme1e-28125
NC_013361:4566779:4586949458694945883491401Escherichia coli O26:H11 str. 11368 chromosome, complete genomeglutamate decarboxylase1e-28125
NC_013353:4313462:4333390433339043347901401Escherichia coli O103:H2 str. 12009, complete genomeglutamate decarboxylase A, PLP-dependent1e-28125
NC_012967:3549880:3595671359567135970711401Escherichia coli B str. REL606 chromosome, complete genomeglutamate decarboxylase A, PLP-dependent1e-28125
NC_009800:3685651:3707491370749137088911401Escherichia coli HS, complete genomeglutamate decarboxylase GadA1e-28125
NC_000913:3624826:3664203366420336656031401Escherichia coli K12, complete genomeglutamate decarboxylase A, PLP-dependent1e-28125
AP010958:4313462:4333390433339043347901401Escherichia coli O103:H2 str. 12009 DNA, complete genomeglutamate decarboxylase A, PLP-dependent1e-28125
NC_011748:3983432:4031288403128840326881401Escherichia coli 55989, complete genomeglutamate decarboxylase A, PLP-dependent1e-28125
CU928145:3983432:4031288403128840326881401Escherichia coli 55989 chromosome, complete genomeglutamate decarboxylase A, PLP-dependent1e-28125
NC_009801:1678790:1680481168048116818811401Escherichia coli E24377A, complete genomeglutamate decarboxylase GadB1e-28125
NC_010658:1593137:1594828159482815962281401Shigella boydii CDC 3083-94, complete genomeglutamate decarboxylase GadB1e-28125
NC_010498:1659328:1680092168009216814921401Escherichia coli SMS-3-5, complete genomeglutamate decarboxylase GadA1e-28125
NC_008258:1750964:1769570176957017709701401Shigella flexneri 5 str. 8401, complete genomeglutamate decarboxylase isozyme1e-28125
NC_016822:1781644:1800442180044218018421401Shigella sonnei 53G, complete genomeglutamate decarboxylase1e-28125
NC_004337:3590323:3695528369552836969281401Shigella flexneri 2a str. 301, complete genomeglutamate decarboxylase isozyme1e-28125
NC_013941:1894496:1896187189618718975871401Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeglutamate decarboxylase beta1e-28125
NC_013364:1902761:1904452190445219058521401Escherichia coli O111:H- str. 11128, complete genomeglutamate decarboxylase1e-28125
NC_013361:2047170:2048861204886120502611401Escherichia coli O26:H11 str. 11368 chromosome, complete genomeglutamate decarboxylase1e-28125
NC_013353:1711656:1713347171334717147471401Escherichia coli O103:H2 str. 12009, complete genomeglutamate decarboxylase B, PLP-dependent1e-28125
NC_011353:2004800:2006491200649120078911401Escherichia coli O157:H7 str. EC4115 chromosome, complete genomeglutamate decarboxylase1e-28125
NC_004741:1792442:1807985180798518093851401Shigella flexneri 2a str. 2457T, complete genomeglutamate decarboxylase isozyme1e-28125
AP010958:1711656:1713347171334717147471401Escherichia coli O103:H2 str. 12009 DNA, complete genomeglutamate decarboxylase B, PLP-dependent1e-28125
NC_015859:3346473:3362573336257333639671395Corynebacterium variabile DSM 44702 chromosome, complete genomeglutamate decarboxylase2e-28124
NC_009380:4944183:4951026495102649524261401Salinispora tropica CNB-440 chromosome, complete genomeglutamate decarboxylase5e-23106
NC_016894:377446:3846103846103860221413Acetobacterium woodii DSM 1030 chromosome, complete genomeglutamate decarboxylase Gad9e-22102
NC_003155:4441559:4457596445759644589601365Streptomyces avermitilis MA-4680, complete genomeglutamate decarboxylase3e-1994
NC_008497:79144:8148981489829281440Lactobacillus brevis ATCC 367, complete genomeGlutamate decarboxylase6e-1580.1
NC_009749:1776600:178975317897531790664912Francisella tularensis subsp. holarctica FTA, complete genomeglutamate decarboxylase4e-1477
NC_009749:1776600:179063917906391790872234Francisella tularensis subsp. holarctica FTA, complete genomeglutamate decarboxylase8e-0959.7
NC_015696:486250:4919754919754930901116Francisella sp. TX077308 chromosome, complete genomeglutamate decarboxylase3e-0650.8