Pre_GI: BLASTP Hits

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Query: NC_008258:2542863:2545379 Shigella flexneri 5 str. 8401, complete genome

Start: 2545379, End: 2546038, Length: 660

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:2586171:258931425893142589973660Shigella flexneri 2002017 chromosome, complete genomeMicrocompartments protein8e-124442
NC_004741:2526421:252981125298112530470660Shigella flexneri 2a str. 2457T, complete genomehypothetical protein8e-124442
NC_004337:2548288:255167725516772552336660Shigella flexneri 2a str. 301, complete genomehypothetical protein8e-124442
NC_010468:1343228:135997613599761360635660Escherichia coli ATCC 8739, complete genomemicrocompartments protein8e-124442
NC_017179:2067015:207746120774612078114654Clostridium difficile BI1, complete genomeethanolamine utilization protein EutL3e-65248
NC_013315:2059007:206945320694532070106654Clostridium difficile CD196 chromosome, complete genomeethanolamine/propanediol utilization protein3e-65248
NC_013192:63111:696396963970292654Leptotrichia buccalis DSM 1135, complete genomemicrocompartments protein2e-64245
NC_009633:286677:297167297167297820654Alkaliphilus metalliredigens QYMF chromosome, complete genomemicrocompartments protein3e-62238
NC_016584:1998000:202666320266632027310648Desulfosporosinus orientis DSM 765 chromosome, complete genomeethanolamine utilization protein5e-62237
NC_003366:1091766:110243611024361103089654Clostridium perfringens str. 13, complete genomeethanolamine utilization protein8e-62236
NC_008261:1048515:105919410591941059847654Clostridium perfringens ATCC 13124, complete genomeethanolamine utilization protein EutL8e-62236
NC_014019:3543389:355409635540963554749654Bacillus megaterium QM B1551 chromosome, complete genomeethanolamine utilization protein EutL9e-62236
NC_013517:1055854:113712811371281137781654Sebaldella termitidis ATCC 33386, complete genomemicrocompartments protein3e-61234
NC_018515:1663912:167236016723601673007648Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeethanolamine utilization protein4e-60231
NC_016584:1714507:171892317189231719570648Desulfosporosinus orientis DSM 765 chromosome, complete genomeethanolamine utilization protein5e-60230
NC_018870:705900:725844725844726500657Thermacetogenium phaeum DSM 12270 chromosome, complete genomeethanolamine utilization protein EutL3e-59228
NC_009253:1381401:139048413904841391137654Desulfotomaculum reducens MI-1 chromosome, complete genomemicrocompartments protein7e-59226
NC_014376:1586649:159808515980851598738654Clostridium saccharolyticum WM1 chromosome, complete genomemicrocompartments protein3e-58224
NC_014654:2277461:228764522876452288298654Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein4e-58224
NC_009922:868262:876516876516877169654Alkaliphilus oremlandii OhILAs, complete genomemicrocompartments protein1e-57222
NC_014614:284005:295997295997296650654Clostridium sticklandii, complete genomeputative carboxysome-related structural protein with role in ethanolamine utilization2e-57221
NC_015275:4493500:450092145009214501574654Clostridium lentocellum DSM 5427 chromosome, complete genomemicrocompartments protein5e-56217
NC_004557:2289135:230027023002702300926657Clostridium tetani E88, complete genomeethanolamine utilization protein eutL5e-54210
NC_011601:2139188:218457721845772185389813Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomepropanediol utilization protein PduB8e-1063.9
NC_014328:1286407:128903012890301289893864Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ethanolamine utilization protein6e-0960.8
NC_014538:985339:990127990127990924798Thermoanaerobacter sp. X513 chromosome, complete genomemicrocompartments protein2e-0859.3
NC_010320:1949852:196342019634201964217798Thermoanaerobacter sp. X514 chromosome, complete genomemicrocompartments protein2e-0859.3
NC_012488:1159463:116395711639571164760804Listeria monocytogenes Clip81459, complete genomePduB protein2e-0858.9
NC_013766:1202713:120591012059101206713804Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein3e-0858.5
NC_013517:1055854:111496611149661115661696Sebaldella termitidis ATCC 33386, complete genomemicrocompartments protein6e-0857.8
NC_009438:212476:230560230560231375816Shewanella putrefaciens CN-32 chromosome, complete genomemicrocompartments protein2e-0755.8
NC_008750:450233:468120468120468935816Shewanella sp. W3-18-1, complete genomemicrocompartment protein2e-0755.8
NC_014654:1113116:111772011177201118553834Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein2e-0652.4