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Query: NC_008258:2542863:2542863 Shigella flexneri 5 str. 8401, complete genome

Start: 2542863, End: 2543762, Length: 900

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:2586171:258679825867982587697900Shigella flexneri 2002017 chromosome, complete genomeCoproporphyrinogen III oxidase, aerobic1e-178625
NC_004337:2548288:254916125491612550060900Shigella flexneri 2a str. 301, complete genomecoproporphyrinogen III oxidase6e-178623
NC_010468:1343228:136225213622521363151900Escherichia coli ATCC 8739, complete genomeCoproporphyrinogen oxidase4e-176617
NC_004741:2526421:252742425274242528194771Shigella flexneri 2a str. 2457T, complete genome2e-149528
NC_008800:1300500:130715213071521308078927Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,coproporphyrinogen III oxidase1e-137489
NC_012880:3748665:376263137626313763566936Dickeya dadantii Ech703, complete genomeCoproporphyrinogen oxidase3e-136484
NC_010634:3155741:317096631709663171895930Yersinia pseudotuberculosis PB1/+, complete genomecoproporphyrinogen III oxidase9e-136483
NC_006155:3237990:325317432531743254103930Yersinia pseudotuberculosis IP 32953, complete genomecoproporphyrinogen III oxidase9e-136483
NC_009708:1497898:150105715010571501986930Yersinia pseudotuberculosis IP 31758 chromosome, complete genomecoproporphyrinogen III oxidase1e-135482
NC_008577:44184:470914709147999909Shewanella sp. ANA-3 chromosome 1, complete sequencecoproporphyrinogen III oxidase1e-130466
NC_015581:1891409:189507618950761896026951Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomeCoproporphyrinogen-III oxidase, aerobic4e-120431
NC_015136:1141925:116432011643201165243924Burkholderia sp. CCGE1001 chromosome 1, complete sequenceCoproporphyrinogen oxidase1e-109396
NC_010084:1054000:107585810758581076781924Burkholderia multivorans ATCC 17616 chromosome 1, completecoproporphyrinogen III oxidase2e-109395
NC_002488:1:170421704217959918Xylella fastidiosa 9a5c, complete genomecoproporphyrinogen III oxidase4e-106384
NC_010577:1:168371683717832996Xylella fastidiosa M23, complete genomeCoproporphyrinogen oxidase1e-104379
NC_004556:1:170331703317950918Xylella fastidiosa Temecula1, complete genomecoproporphyrinogen III oxidase2e-104378
NC_015138:2299100:230038023003802301351972Acidovorax avenae subsp. avenae ATCC 19860 chromosome, completeCoproporphyrinogen oxidase1e-102373
NC_008752:3511006:352933335293333530304972Acidovorax avenae subsp. citrulli AAC00-1, complete genomeCoproporphyrinogen oxidase1e-102372
NC_008817:1538507:1557131155713115581591029Prochlorococcus marinus str. MIT 9515, complete genomeCoproporphyrinogen III oxidase2e-89329
NC_013037:2906730:292453229245322925443912Dyadobacter fermentans DSM 18053, complete genomeCoproporphyrinogen oxidase2e-71269
NC_013730:2751484:277366627736662774580915Spirosoma linguale DSM 74, complete genomeCoproporphyrinogen oxidase2e-70265
NC_006833:902744:922687922687923511825Wolbachia endosymbiont strain TRS of Brugia malayi, completecoproporphyrinogen III oxidase6e-54211
NC_014006:2999500:303977530397753040626852Sphingobium japonicum UT26S chromosome 1, complete genomecoproporphyrinogen III oxidase3e-51202