Pre_GI: BLASTP Hits

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Query: NC_008258:1076922:1098649 Shigella flexneri 5 str. 8401, complete genome

Start: 1098649, End: 1100249, Length: 1601

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004431:3409389:342647934264793426855377Escherichia coli CFT073, complete genomeRNase P, RNA component6e-63242
NC_013941:4470932:447608144760814476314234Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein7e-0755.8
NC_002695:4584177:458858945885894588822234Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein7e-0755.8