Pre_GI: BLASTP Hits

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Query: NC_008258:1076922:1098153 Shigella flexneri 5 str. 8401, complete genome

Start: 1098153, End: 1098608, Length: 456

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004337:1065609:108011110801111080566456Shigella flexneri 2a str. 301, complete genomeminor curlin subunit precursor3e-73273
NC_000913:1087062:110317411031741103629456Escherichia coli K12, complete genomecurlin nucleator protein, minor subunit in curli complex5e-73272
AC_000091:1083798:110419211041921104647456Escherichia coli W3110 DNA, complete genomecurlin nucleator protein, minor subunit in curli complex5e-73272
NC_013716:1178383:120132712013271201782456Citrobacter rodentium ICC168, complete genomeminor curlin subunit2e-62237
NC_006905:1186895:121121812112181211673456Salmonella enterica subsp. enterica serovar Choleraesuis strminor curlin subunit precursor, nucleator for assembly of adhesive surface organelles5e-62236
NC_011080:1209935:123292012329201233375456Salmonella enterica subsp. enterica serovar Newport str. SL254,minor curlin protein CsgB5e-62236
NC_003197:1207597:123113312311331231588456Salmonella typhimurium LT2, complete genomeminor curlin subunit precursor5e-62236
NC_016863:1165232:118858611885861189041456Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1curlin minor subunit5e-62236
NC_003198:1117687:114140911414091141864456Salmonella enterica subsp. enterica serovar Typhi str. CT18,nucleation component of curlin monomers3e-62236
NC_017046:1164176:118731911873191187801483Salmonella enterica subsp. enterica serovar Typhimurium str. 798curlin monomer nucleation protein6e-62235
NC_016860:1205282:122879212287921229274483Salmonella enterica subsp. enterica serovar Typhimurium strminor curlin protein CsgB6e-62235
NC_011083:1216500:123548112354811235936456Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,minor curlin protein CsgB1e-61234
NC_016514:1701273:170901317090131709504492Enterobacter cloacae EcWSU1 chromosome, complete genomeMinor curlin subunit5e-54209
NC_014121:2629075:264073326407332641188456Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeminor curlin subunit6e-51199
NC_015968:1709680:171923417192341719689456Enterobacter asburiae LF7a chromosome, complete genomeCurlin associated repeat-containing protein8e-51198
NC_018868:1960542:201483420148342015388555Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomePPE repeat-containing protein8e-1062.8
NC_013730:7355010:7363844736384473655801737Spirosoma linguale DSM 74, complete genomeCurlin associated repeat protein2e-0651.6