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Query: NC_008258:1076922:1095914 Shigella flexneri 5 str. 8401, complete genome

Start: 1095914, End: 1096330, Length: 417

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000913:1087062:110093411009341101350417Escherichia coli K12, complete genomepredicted transport protein2e-64243
AC_000091:1083798:110195211019521102368417Escherichia coli W3110 DNA, complete genomepredicted transport protein2e-64243
NC_003198:1117687:113916011391601139576417Salmonella enterica subsp. enterica serovar Typhi str. CT18,assembly/transport component in curli production2e-58223
NC_006905:1186895:120897012089701209386417Salmonella enterica subsp. enterica serovar Choleraesuis strcurli production assembly/transport component, 2nd curli operon2e-58223
NC_003197:1207597:122888512288851229301417Salmonella typhimurium LT2, complete genomecurli production assembly/transport component2e-58223
NC_011080:1209935:123067212306721231088417Salmonella enterica subsp. enterica serovar Newport str. SL254,curli production assembly/transport component CsgF2e-58223
NC_011083:1216500:123323412332341233650417Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,curli production assembly/transport component CsgF2e-58223
NC_011094:1166271:118719211871921187608417Salmonella enterica subsp. enterica serovar Schwarzengrund strcurli assembly protein CsgF2e-58223
NC_011205:2137696:213769621376962138112417Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853curli assembly protein CsgF2e-58223
NC_011294:2009388:200938820093882009804417Salmonella enterica subsp. enterica serovar Enteritidis strcurli assembly protein CsgF2e-58223
NC_016810:1163919:118502511850251185441417Salmonella enterica subsp. enterica serovar Typhimurium strassembly/transport component in curli production2e-58223
NC_016863:1165232:118633811863381186754417Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1curli assembly protein CsgF2e-58223
NC_016860:1205282:122657112265711226987417Salmonella enterica subsp. enterica serovar Typhimurium strcurli assembly protein CsgF2e-58223
NC_016857:1163919:118502511850251185441417Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74curli assembly protein CsgF2e-58223
NC_016856:1165941:118704711870471187463417Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Scurli assembly protein CsgF2e-58223
NC_016832:1838220:183864218386421839058417Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,Curli production assembly/transport component csgF2e-58223
NC_016831:947281:991917991917992333417Salmonella enterica subsp. enterica serovar Gallinarum/pullorumassembly/transport component in curli production2e-58223
NC_013716:1178383:119909611990961199512417Citrobacter rodentium ICC168, complete genomecurli production assembly/transport component8e-58221
NC_014121:2629075:264300126430012643414414Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completecurli assembly protein CsgF1e-54211
NC_015968:1709680:171699517169951717408414Enterobacter asburiae LF7a chromosome, complete genomeCurli production assembly/transport component CsgF1e-54211
NC_017046:1164176:118509811850981185493396Salmonella enterica subsp. enterica serovar Typhimurium str. 798assembly/transport component in curli production1e-53207
NC_016514:1701273:170680217068021707215414Enterobacter cloacae EcWSU1 chromosome, complete genomecurli production assembly/transport component CsgF1e-52204
NC_018868:1960542:201336720133672013765399Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomecurli fiber protein CsgF3e-0960.5