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Query: NC_008258:1076922:1095181 Shigella flexneri 5 str. 8401, complete genome

Start: 1095181, End: 1095887, Length: 707

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000913:1087062:110007411000741100907834Escherichia coli K12, complete genomeouter membrane lipoprotein6e-43174
AC_000091:1083798:110109211010921101925834Escherichia coli W3110 DNA, complete genomeouter membrane lipoprotein6e-43174
NC_010067:1782998:178299817829981783809812Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, complete7e-41167
NC_013716:1178383:119823711982371199070834Citrobacter rodentium ICC168, complete genomecurli production assembly/transport component1e-39162
NC_014121:2629075:264344126434412644274834Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completecurli production assembly/transport component CsgG1e-39162
NC_016514:1701273:170594217059421706775834Enterobacter cloacae EcWSU1 chromosome, complete genomecurli production assembly/transport component CsgG1e-38159
NC_015968:1709680:171613517161351716968834Enterobacter asburiae LF7a chromosome, complete genomeCurli production assembly/transport component CsgG1e-38159
NC_004631:1842050:184205018420501842883834Salmonella enterica subsp. enterica serovar Typhi Ty2, completeassembly/transport component in curli production1e-34146
NC_010102:1979742:197974219797421980575834Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein1e-34146
NC_011083:1216500:123237412323741233207834Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,curli production assembly/transport component CsgG1e-34146
NC_006511:1770000:177001817700181770851834Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCassembly/transport component in curli production1e-34146
NC_003197:1207597:122802512280251228858834Salmonella typhimurium LT2, complete genomeputative curli operon transcriptional regulator1e-34146
NC_006905:1186895:120811012081101208943834Salmonella enterica subsp. enterica serovar Choleraesuis strputative transcriptional regulator in curly assembly/transport, 2nd curli operon1e-34146
NC_011080:1209935:122981212298121230645834Salmonella enterica subsp. enterica serovar Newport str. SL254,curli production assembly/transport component CsgG1e-34146
NC_003198:1117687:113830011383001139133834Salmonella enterica subsp. enterica serovar Typhi str. CT18,assembly/transport component in curli production1e-34146
NC_011094:1166271:118633211863321187165834Salmonella enterica subsp. enterica serovar Schwarzengrund strcurli production assembly/transport component CsgG1e-34146
NC_011147:1763681:176520117652011766034834Salmonella enterica subsp. enterica serovar Paratyphi A strassembly/transport component in curli production1e-34146
NC_016863:1165232:118547811854781186311834Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1putative curli operon transcriptional regulator1e-34146
NC_016860:1205282:122571112257111226544834Salmonella enterica subsp. enterica serovar Typhimurium strcurli assembly/transport protein CsgG1e-34146
NC_016857:1163919:118416511841651184998834Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74assembly/transport component in curli production1e-34146
NC_016856:1165941:118618711861871187020834Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Sputative curli operon transcriptional regulator1e-34146
NC_016832:1838220:183908518390851839918834Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,Curli production assembly/transport component csgG1e-34146
NC_016831:947281:991057991057991890834Salmonella enterica subsp. enterica serovar Gallinarum/pullorumassembly/transport component in curli production1e-34146
NC_012125:2646792:264679226467922647625834Salmonella enterica subsp. enterica serovar Paratyphi C strainassembly/transport component in curli production1e-34146
NC_011205:2137696:213813921381392138972834Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853curli production assembly/transport component CsgG1e-34146
NC_017046:1164176:118423811842381184984747Salmonella enterica subsp. enterica serovar Typhimurium str. 798assembly/transport component in curli production7e-26117
NC_016810:1163919:118416511841651184911747Salmonella enterica subsp. enterica serovar Typhimurium strassembly/transport component in curli production7e-26117
NC_011294:2009388:200991820099182010664747Salmonella enterica subsp. enterica serovar Enteritidis strassembly/transport component in curli production7e-26117
NC_018868:1960542:201378220137822014183402Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomecurli production assembly/transport protein CsgG5e-1478.2