Pre_GI: BLASTP Hits

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Query: NC_008258:1076922:1094509 Shigella flexneri 5 str. 8401, complete genome

Start: 1094509, End: 1095048, Length: 540

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004337:1065609:107514710751471075668522Shigella flexneri 2a str. 301, complete genomehypothetical protein6e-92335
NC_010468:2809125:280912528091252809646522Escherichia coli ATCC 8739, complete genomeprotein of unknown function DUF10979e-92335
AC_000091:1083798:110053711005371101028492Escherichia coli W3110 DNA, complete genomepredicted inner membrane protein4e-86316
NC_000913:1087062:109951910995191100010492Escherichia coli K12, complete genomepredicted inner membrane protein4e-86316
NC_011147:1763681:176607317660731766603531Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein1e-78292
NC_006511:1770000:177089017708901771420531Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein1e-78292
NC_003198:1117687:113773211377321138262531Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein2e-78291
NC_004631:1842050:184292118429211843451531Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein2e-78291
NC_016810:1163919:118359611835961184126531Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein2e-78291
NC_016856:1165941:118561811856181186148531Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Sputative inner membrane protein2e-78291
NC_016857:1163919:118359611835961184126531Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74putative inner membrane protein2e-78291
NC_016863:1165232:118490911849091185439531Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1putative inner membrane protein2e-78291
NC_006905:1186895:120754212075421208072531Salmonella enterica subsp. enterica serovar Choleraesuis strputative inner membrane protein2e-78290
NC_011294:2009388:201070320107032011233531Salmonella enterica subsp. enterica serovar Enteritidis strhypothetical protein5e-78290
NC_003197:1207597:122745612274561227986531Salmonella typhimurium LT2, complete genomeputative inner membrane protein2e-77287
NC_010102:1979742:198061419806141981138525Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-77287
NC_017046:1164176:118367511836751184199525Salmonella enterica subsp. enterica serovar Typhimurium str. 798hypothetical protein4e-77286
NC_016831:947281:990494990494991018525Salmonella enterica subsp. enterica serovar Gallinarum/pullorumhypothetical protein2e-76284
NC_011094:1166271:118578111857811186293513Salmonella enterica subsp. enterica serovar Schwarzengrund strhypothetical protein4e-76283
NC_011205:2137696:213901121390112139523513Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein1e-75282
NC_013716:1178383:119764711976471198177531Citrobacter rodentium ICC168, complete genomehypothetical protein2e-75280
NC_016832:1838220:183995618399561840450495Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,Inner membrane protein ycdZ2e-74278
NC_011083:1216500:123184112318411232335495Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,inner membrane protein YcdZ2e-74278
NC_011080:1209935:122927912292791229773495Salmonella enterica subsp. enterica serovar Newport str. SL254,inner membrane protein YcdZ5e-74276
NC_016860:1205282:122517812251781225672495Salmonella enterica subsp. enterica serovar Typhimurium strinner membrane protein YcdZ1e-73275
NC_010067:1782998:178385117838511784345495Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein3e-73274
NC_012125:2646792:264766326476632648157495Salmonella enterica subsp. enterica serovar Paratyphi C strainhypothetical protein3e-73273
NC_015968:1709680:171560017156001716091492Enterobacter asburiae LF7a chromosome, complete genomehypothetical protein5e-72269
NC_016514:1701273:170536817053681705898531Enterobacter cloacae EcWSU1 chromosome, complete genomeinner membrane protein YcdZ1e-70265
NC_015663:3466471:350172135017213502203483Enterobacter aerogenes KCTC 2190 chromosome, complete genomehypothetical protein2e-70264
NC_008800:1497746:151399715139971514488492Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein3e-60230
NC_015224:3191000:319178131917813192272492Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein4e-60230
NC_014121:2629075:264431826443182644740423Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completehypothetical protein1e-58225
NC_009778:2227627:223568722356872236163477Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein1e-40166
NC_015425:405058:408528408528408995468Clostridium botulinum BKT015925 chromosome, complete genomeglutathione-regulated potassium-efflux system protein3e-26117