Some Help

Query: NC_008258:1076922:1090646 Shigella flexneri 5 str. 8401, complete genome

Start: 1090646, End: 1091632, Length: 987

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:1075535:108119310811931082179987Shigella flexneri 2002017 chromosome, complete genomehypothetical protein2e-180631
NC_004337:1065609:107126610712661072252987Shigella flexneri 2a str. 301, complete genomehypothetical protein2e-180631
AC_000091:1083798:109626510962651097251987Escherichia coli W3110 DNA, complete genomepredicted inner membrane protein4e-176617
NC_000913:1087062:109506610950661096052987Escherichia coli K12, complete genomepredicted inner membrane protein4e-176617
NC_010468:2809125:281290228129022813888987Escherichia coli ATCC 8739, complete genomehypothetical protein4e-175613
NC_002695:1364833:136927713692771370263987Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein8e-174609
NC_002655:1448605:145304914530491454035987Escherichia coli O157:H7 EDL933, complete genomehypothetical protein8e-174609
NC_011353:1307106:131155013115501312536987Escherichia coli O157:H7 str. EC4115 chromosome, complete genomehypothetical protein8e-174609
NC_013008:1307392:131183613118361312822987Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeinner membrane protein8e-174609
NC_014837:1873020:189845518984551899450996Pantoea sp. At-9b chromosome, complete genomeputative inner membrane protein4e-68258
NC_015663:2694373:272068427206842721673990Enterobacter aerogenes KCTC 2190 chromosome, complete genomeputative inner membrane protein3e-62239
NC_020181:2714559:272409727240972725083987Enterobacter aerogenes EA1509E, complete genomehypothetical protein3e-60232