Pre_GI: BLASTP Hits

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Query: NC_008258:1076922:1090157 Shigella flexneri 5 str. 8401, complete genome

Start: 1090157, End: 1090537, Length: 381

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:1075535:108070410807041081084381Shigella flexneri 2002017 chromosome, complete genomeputative (acyl-carrier-protein) S-malonyltransferase2e-70263
NC_013008:1307392:131089513108951311839945Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeacyl transferase5e-63239
NC_011353:1307106:131060913106091311553945Escherichia coli O157:H7 str. EC4115 chromosome, complete genomemalonyl CoA-acyl carrier protein transacylase5e-63239
NC_020181:2714559:272508527250852726023939Enterobacter aerogenes EA1509E, complete genomehypothetical protein2e-33140
NC_015663:2694373:271974427197442720673930Enterobacter aerogenes KCTC 2190 chromosome, complete genomeMalonyl CoA-acyl carrier protein transacylase2e-33140
NC_014837:1873020:189751918975191898439921Pantoea sp. At-9b chromosome, complete genomeacyl transferase1e-31135
NC_010468:2809125:281388528138852814208324Escherichia coli ATCC 8739, complete genomehypothetical protein2e-29127
NC_002695:1364833:136895713689571369280324Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein8e-29125
NC_002655:1448605:145272914527291453052324Escherichia coli O157:H7 EDL933, complete genomehypothetical protein8e-29125
AC_000091:1083798:109596610959661096268303Escherichia coli W3110 DNA, complete genome3e-25113
NC_000913:1087062:109476710947671095069303Escherichia coli K12, complete genomehypothetical protein3e-25113
NC_008786:2850736:287694628769462877893948Verminephrobacter eiseniae EF01-2, complete genomeacyl transferase domain protein2e-1374.3
NC_019940:1540434:1569780156978015768447065Thioflavicoccus mobilis 8321 chromosome, complete genomepolyketide synthase family protein8e-1062.4
NC_014033:772754:793766793766794656891Prevotella ruminicola 23 chromosome, complete genome[acyl-carrier-protein] S-malonyltransferase1e-0962
NC_009718:643200:679087679087679986900Fervidobacterium nodosum Rt17-B1, complete genomemalonyl CoA-acyl carrier protein transacylase2e-0961.2
NC_012811:1:2477924779267491971Methylobacterium extorquens AM1 megaplasmid, complete sequenceputative malonyl-CoA-acyl-carrier-protein2e-0960.8
NC_011565:1054414:105803310580331058905873Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,malonyl CoA-acyl carrier protein transacylase2e-0960.8
NC_015571:440605:445545445545446426882Porphyromonas gingivalis TDC60, complete genomemalonyl CoA-acyl carrier protein transacylase5e-0960.1
NC_009879:260000:260563260563261450888Rickettsia canadensis str. McKiel, complete genomehypothetical protein4e-0960.1
NC_016929:258500:260309260309261244936Rickettsia canadensis str. CA410 chromosome, complete genomeacyl-carrier-protein S-malonyltransferase4e-0960.1
NC_010729:265791:270731270731271612882Porphyromonas gingivalis ATCC 33277, complete genomemalonyl CoA-acyl carrier protein transacylase5e-0959.7
NC_002950:155873:160813160813161694882Porphyromonas gingivalis W83, complete genomemalonyl CoA-acyl carrier protein transacylase5e-0959.7
NC_012026:75812:8680286802878211020Anaplasma marginale str. Florida, complete genomemalonyl CoA-acyl carrier protein transacylase (fabD)7e-0959.3
NC_015690:1818333:1907120190712019095282409Paenibacillus mucilaginosus KNP414 chromosome, complete genomePksE7e-0959.3
NC_019978:1410041:142038614203861421315930Halobacteroides halobius DSM 5150, complete genomemalonyl CoA-acyl carrier protein transacylase7e-0959.3
NC_016935:2347691:2438318243831824407262409Paenibacillus mucilaginosus 3016 chromosome, complete genomePksE protein7e-0959.3
NC_012491:4231469:4231469423146942347713303Brevibacillus brevis NBRC 100599, complete genomehypothetical protein9e-0958.9
NC_016938:1492486:150084115008411501773933Melissococcus plutonius DAT561 chromosome 1, complete genomemalonyl CoA-acyl carrier protein transacylase1e-0858.9
NC_020126:6791726:681473368147336815608876Myxococcus stipitatus DSM 14675, complete genomemalonyl CoA-acyl carrier protein transacylase1e-0858.2
NS_000191:870160:882611882611883540930Uncultured Termite group 1 bacterium phylotype Rs-D17, completeS-malonyltransferase2e-0857.8
NC_020419:870160:882611882611883540930Uncultured Termite group 1 bacterium phylotype Rs-D17 DNA, completeS-malonyltransferase2e-0857.8
NC_015275:3299923:331030833103083311252945Clostridium lentocellum DSM 5427 chromosome, complete genomemalonyl CoA-acyl carrier protein transacylase2e-0857.4
NC_009483:3644677:3670973367097336732672295Geobacter uraniireducens Rf4 chromosome, complete genomemalonyl CoA-acyl carrier protein transacylase4e-0857
NC_007354:1087456:109274910927491093729981Ehrlichia canis str. Jake, complete genomeMalonyl CoA-acyl carrier protein transacylase5e-0856.6
NC_009483:3608000:3613915361391536151471233Geobacter uraniireducens Rf4 chromosome, complete genomemalonyl CoA-acyl carrier protein transacylase7e-0855.8
NC_014622:2114244:212811421281142129055942Paenibacillus polymyxa SC2 chromosome, complete genomemalonyl CoA-ACP transacylase2e-0754.7
NC_013939:148706:156015156015156941927Deferribacter desulfuricans SSM1, complete genomeACP S-malonyltransferase2e-0754.3
NC_014103:4059905:406558440655844066528945Bacillus megaterium DSM319 chromosome, complete genomemalonyl CoA-acyl carrier protein transacylase5e-0753.1
NC_014483:1954856:196871319687131969657945Paenibacillus polymyxa E681 chromosome, complete genomeMalonyl CoA-acyl carrier protein transacylase (MCT)8e-0752.4
NC_010831:173499:176731176731177642912Chlorobium phaeobacteroides BS1, complete genomemalonyl CoA-acyl carrier protein transacylase8e-0752.4
NC_014958:3393855:340911734091173410043927Deinococcus maricopensis DSM 21211 chromosome, complete genomemalonyl CoA-acyl carrier protein transacylase1e-0652
NC_002973:1846000:186150218615021862443942Listeria monocytogenes str. 4b F2365, complete genomeacyl-carrier-protein S-malonyltransferase2e-0651.6
NC_011027:136954:148732148732149643912Chlorobaculum parvum NCIB 8327, complete genomemalonyl CoA-acyl carrier protein transacylase2e-0651.2
NC_011898:2713912:2717898271789827191271230Clostridium cellulolyticum H10, complete genomemalonyl CoA-acyl carrier protein transacylase2e-0650.8
NC_014960:1950648:1968051196805119764688418Anaerolinea thermophila UNI-1, complete genomebeta-ketoacyl synthase family protein2e-0650.8
NC_016830:4295831:431532543153254316173849Pseudomonas fluorescens F113 chromosome, complete genomeprotein LkcD4e-0650.4
NC_016111:167949:14957514957516795218378Streptomyces cattleya NRRL 8057, complete genome6-methylsalicylic acid synthase4e-0650.1
NC_016111:134444:14957514957516795218378Streptomyces cattleya NRRL 8057, complete genome6-methylsalicylic acid synthase4e-0650.1
NC_014722:1647978:1655795165579516577921998Burkholderia rhizoxinica HKI 454, complete genomeMalonyl-CoA-[acyl-carrier-protein] transacylase7e-0649.3
NC_009848:1542978:154457415445741545518945Bacillus pumilus SAFR-032, complete genome[Acyl-carrier-protein] S-malonyltransferase8e-0649.3