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Query: NC_008258:1076922:1082571 Shigella flexneri 5 str. 8401, complete genome

Start: 1082571, End: 1084994, Length: 2424

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013941:1314158:1317502131750213199252424Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeBiofilm PGA synthesis protein pgaA precursor01565
NC_002695:1329472:1332817133281713352402424Escherichia coli O157:H7 str. Sakai, complete genomeputative outer membrane protein01565
NC_000913:1087062:1089089108908910915122424Escherichia coli K12, complete genomepredicted outer membrane protein01565
NC_010468:2809125:2817442281744228198652424Escherichia coli ATCC 8739, complete genomeTetratricopeptide TPR_2 repeat protein01565
AC_000091:1083798:1090288109028810927112424Escherichia coli W3110 DNA, complete genomepredicted outer membrane protein01565
NC_011353:1271335:1275095127509512775182424Escherichia coli O157:H7 str. EC4115 chromosome, complete genomeouter membrane protein PgaA01565
NC_013008:1271621:1275381127538112778042424Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeouter membrane protein PgaA01565
NC_002655:1413244:1416589141658914190122424Escherichia coli O157:H7 EDL933, complete genomeputative outer membrane protein01560
NC_007946:1073135:1076480107648010789032424Escherichia coli UTI89, complete genomehypothetical protein YcdS precursor01528
NC_004431:1119700:1123045112304511254682424Escherichia coli CFT073, complete genomeHypothetical protein ycdS precursor01528