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Query: NC_008258:1076922:1078035 Shigella flexneri 5 str. 8401, complete genome

Start: 1078035, End: 1078448, Length: 414

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013008:1271621:127162112716211272034414Escherichia coli O157:H7 str. TW14359 chromosome, complete genomePGA biosynthesis protein1e-65247
NC_011353:1271335:127133512713351271748414Escherichia coli O157:H7 str. EC4115 chromosome, complete genomePGA biosynthesis protein1e-65247
NC_010468:2809125:282321228232122823625414Escherichia coli ATCC 8739, complete genomehypothetical protein1e-65247
AC_000091:1083798:108652810865281086941414Escherichia coli W3110 DNA, complete genomepredicted inner membrane protein1e-65247