Pre_GI: BLASTP Hits

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Query: NC_008150:4561633:4569438 Yersinia pestis Antiqua, complete genome

Start: 4569438, End: 4569596, Length: 159

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009381:3596000:360767836076783607836159Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein2e-23107
NC_008149:402599:410405410405410563159Yersinia pestis Nepal516, complete genomehypothetical protein2e-23107
NC_017265:3982020:399258839925883992746159Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein2e-23107
NC_010159:809663:821272821272821430159Yersinia pestis Angola, complete genomehypothetical protein2e-23107
NC_005810:4224500:423367942336794233837159Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-23107
NC_004088:4116676:412724441272444127402159Yersinia pestis KIM, complete genomehypothetical protein2e-23107
NC_009708:3903598:391416739141673914325159Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein2e-22103