Pre_GI: BLASTP Hits

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Query: NC_008150:4373722:4391291 Yersinia pestis Antiqua, complete genome

Start: 4391291, End: 4391602, Length: 312

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:687471:705040705040705351312Yersinia pestis A1122 chromosome, complete genomeputative biofilm stress and motility protein A3e-54209
NC_017154:394401:396116396116396427312Yersinia pestis D106004 chromosome, complete genomeputative lipoprotein3e-54209
NC_014029:452248:453963453963454274312Yersinia pestis Z176003 chromosome, complete genomeputative lipoprotein3e-54209
NC_003143:398748:400463400463400774312Yersinia pestis CO92, complete genomeputative lipoprotein3e-54209
NC_012214:594667:597989597989598357369Erwinia pyrifoliae Ep1/96, complete genomehypothetical protein YjfO5e-1166.6