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Query: NC_008150:4373722:4384629 Yersinia pestis Antiqua, complete genome

Start: 4384629, End: 4385096, Length: 468

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:4306716:431745243174524317919468Yersinia pestis biovar Microtus str. 91001, complete genomeUDP-glucose pyrophosphorylase2e-84310
NC_008149:318860:326177326177326644468Yersinia pestis Nepal516, complete genomehypothetical protein2e-84310
NC_003143:398748:406969406969407436468Yersinia pestis CO92, complete genomehypothetical protein2e-84310
NC_004088:4202247:421315442131544213621468Yersinia pestis KIM, complete genomehypothetical protein2e-84310
NC_016818:2836851:286924928692492869565317Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, complete8e-35145
NC_014500:2019113:203621520362152036463249Dickeya dadantii 3937 chromosome, complete genomehypothetical protein7e-1063.2
NC_020911:2921925:293665329366532936985333Octadecabacter antarcticus 307, complete genomeputative IS3-family mobile element-associated protein2e-0754.7