Pre_GI: BLASTP Hits

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Query: NC_008150:2878450:2897240 Yersinia pestis Antiqua, complete genome

Start: 2897240, End: 2898478, Length: 1239

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004088:1196875:1208849120884912102041356Yersinia pestis KIM, complete genomeO-unit flippase-like protein0656
NC_008149:1122693:1136816113681611380541239Yersinia pestis Nepal516, complete genomeO-unit flippase0656
NC_017265:3240379:3259161325916132605041344Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative O-unit flippase0655
NC_014029:3501500:3519972351997235213151344Yersinia pestis Z176003 chromosome, complete genomeputative O-unit flippase0655
NC_009381:3094939:3113713311371331149511239Yersinia pestis Pestoides F chromosome, complete genomeO-unit flippase0655
NC_010634:1175404:1187506118750611888491344Yersinia pseudotuberculosis PB1/+, complete genomeO-unit flippase-like protein0652
NC_006155:1191307:1205339120533912066821344Yersinia pseudotuberculosis IP 32953, complete genomeputative O-unit flippase5e-170597
NC_009708:3411153:3429631342963134309741344Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeO-unit flippase protein Wzx5e-170597
NC_014624:2211771:2211771221177122132011431Eubacterium limosum KIST612 chromosome, complete genomepolysaccharide biosynthesis protein6e-27122
NC_015578:61820:7085970859722201362Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein1e-24114
NC_015738:760309:7731497731497745821434Eggerthella sp. YY7918, complete genomehypothetical protein1e-23110
NC_015873:924392:9498669498669512901425Megasphaera elsdenii DSM 20460, complete genomehypothetical protein3e-23109
NC_015052:471944:4875504875504889831434Bifidobacterium longum subsp. infantis 157F, complete genomehypothetical protein2e-1790.5
NC_014355:2321957:2332141233214123335561416Candidatus Nitrospira defluvii, complete genomehypothetical protein4e-0962.8