Pre_GI: BLASTP Hits

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Query: NC_008150:2878450:2894994 Yersinia pestis Antiqua, complete genome

Start: 2894994, End: 2896136, Length: 1143

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:3240379:3256915325691532580571143Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative mannosyltransferase0697
NC_004088:1196875:1211308121130812124501143Yersinia pestis KIM, complete genomemannosyltransferase protein0697
NC_010159:1288000:1302674130267413038161143Yersinia pestis Angola, complete genomeputative mannosyltransferase WbyJ0697
NC_005810:872672:8891358891358902771143Yersinia pestis biovar Microtus str. 91001, complete genomeputative mannosyltransferase0697
NC_006155:1191307:1207848120784812089901143Yersinia pseudotuberculosis IP 32953, complete genomeputative mannosyltransferase0697
NC_003143:3446740:3463321346332134644631143Yersinia pestis CO92, complete genomeputative mannosyltransferase0697
NC_009381:3094939:3111467311146731126091143Yersinia pestis Pestoides F chromosome, complete genomemannosyltransferase0697
NC_009708:3411153:3427323342732334284651143Yersinia pseudotuberculosis IP 31758 chromosome, complete genomemannosyltransferase WbyJ0697
NC_014029:3501500:3517726351772635188681143Yersinia pestis Z176003 chromosome, complete genomeputative mannosyltransferase0697
NC_017154:3444497:3460733346073334618751143Yersinia pestis D106004 chromosome, complete genomeputative mannosyltransferase0697
NC_017160:3426486:3442733344273334438751143Yersinia pestis D182038 chromosome, complete genomeputative mannosyltransferase0697
NC_017168:2281040:2297505229750522986471143Yersinia pestis A1122 chromosome, complete genomeputative mannosyltransferase0697
NC_008149:1122693:1139158113915811403001143Yersinia pestis Nepal516, complete genomemannosyltransferase0695
NC_015703:5391478:5415886541588654171361251Runella slithyformis DSM 19594 chromosome, complete genomegroup 1 glycosyl transferase2e-0860.5
NC_015500:987641:1004681100468110057871107Treponema brennaborense DSM 12168 chromosome, complete genomeglycosyl transferase group 15e-0755.8
NC_015500:2197000:2211627221162722127331107Treponema brennaborense DSM 12168 chromosome, complete genomehypothetical protein7e-0755.5
NC_011283:1690193:1708738170873817099071170Klebsiella pneumoniae 342 chromosome, complete genomehypothetical protein2e-0653.9