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Query: NC_008150:2599661:2620889 Yersinia pestis Antiqua, complete genome

Start: 2620889, End: 2621413, Length: 525

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017154:2901300:292252929225292923053525Yersinia pestis D106004 chromosome, complete genomeco-chaperone HscB2e-88323
NC_012559:2752825:276876827687682769283516Laribacter hongkongensis HLHK9, complete genomehypothetical protein1e-24112
NC_017512:1264542:127987112798711280371501Neisseria meningitidis WUE 2594, complete genomeco-chaperone protein Hsc201e-1789.4
NC_003116:1488576:150390515039051504405501Neisseria meningitidis Z2491, complete genomechaperone protein1e-1789.4
NC_017505:1338661:135602413560241356524501Neisseria meningitidis alpha710 chromosome, complete genomechaperone protein2e-1788.6
NC_013016:1257942:127587312758731276373501Neisseria meningitidis alpha14 chromosome, complete genomechaperone protein2e-1788.2
NC_017516:917817:921739921739922239501Neisseria meningitidis H44/76 chromosome, complete genomeFe-S protein assembly co-chaperone HscB2e-1788.2
NC_017517:1377617:139426313942631394763501Neisseria meningitidis M01-240355 chromosome, complete genomeFe-S protein assembly co-chaperone HscB2e-1788.2
NC_008786:2687688:268813926881392688675537Verminephrobacter eiseniae EF01-2, complete genomeco-chaperone Hsc206e-1787
NC_011035:1033942:105079810507981051298501Neisseria gonorrhoeae NCCP11945 chromosome, complete genomechaperone protein HscB4e-1684.3
NC_017511:950411:966593966593967093501Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomechaperone protein HscB4e-1684.3
NC_008095:6253610:625451462545146255101588Myxococcus xanthus DK 1622, complete genomeFe-S protein assembly co-chaperone HscB2e-1582
NC_008576:3812500:382681738268173827440624Magnetococcus sp. MC-1, complete genomeco-chaperone Hsc204e-1580.9
NC_010162:10208521:102250871022508710225623537Sorangium cellulosum 'So ce 56', complete genomeputative co-chaperone Hsc202e-1375.5
NC_007109:1105251:112375411237541124254501Rickettsia felis URRWXCal2, complete genomeco-chaperone HscB5e-1373.9
NC_003103:266013:267791267791268291501Rickettsia conorii str. Malish 7, complete genomeco-chaperone HscB7e-1373.2
NC_007797:692944:697597697597698037441Anaplasma phagocytophilum HZ, complete genomeco-chaperone protein hscB5e-0960.5
NC_002946:618439:621287621287621640354Neisseria gonorrhoeae FA 1090, complete genomeputative chaperone protein HscB7e-0856.6