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Query: NC_008150:2599661:2618126 Yersinia pestis Antiqua, complete genome

Start: 2618126, End: 2618326, Length: 201

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005125:2366778:237334523733452373551207Gloeobacter violaceus PCC 7421, complete genomehypothetical protein1e-1582
NC_008576:3812500:382425738242573824451195Magnetococcus sp. MC-1, complete genomeprotein of unknown function DUF5283e-1373.6
NC_012559:2752825:276581127658112766005195Laribacter hongkongensis HLHK9, complete genomeDUF528 domain containing protein4e-1270.1
NC_010981:242500:243268243268243462195Wolbachia pipientis, complete genomehypothetical protein2e-0961.2
NC_015722:1050023:105344910534491053652204Candidatus Midichloria mitochondrii IricVA chromosome, completehypothetical protein6e-0856.2