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Query: NC_008150:2599661:2600688 Yersinia pestis Antiqua, complete genome

Start: 2600688, End: 2601437, Length: 750

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2560000:256228725622872563036750Yersinia pestis A1122 chromosome, complete genometype IV pilus biogenesis/stability protein PilW6e-137486
NC_010159:409500:435812435812436561750Yersinia pestis Angola, complete genometype IV pilus biogenesis/stability protein PilW6e-137486
NC_010634:3269010:327627932762793277028750Yersinia pseudotuberculosis PB1/+, complete genometype IV pilus biogenesis/stability protein PilW4e-136483
NC_017154:2901300:290232729023272902797471Yersinia pestis D106004 chromosome, complete genomefimbrial biogenesis protein2e-80298
NC_015222:1127675:113577411357741136553780Nitrosomonas sp. AL212 chromosome, complete genometype IV pilus biogenesis/stability protein PilW2e-1169.3
NC_008781:1973826:199394819939481994754807Polaromonas naphthalenivorans CJ2, complete genometype IV pilus biogenesis/stability protein PilW5e-1168.2
NC_008740:1815743:1815743181574318184452703Marinobacter aquaeolei VT8, complete genomeTetratricopeptide TPR_2 repeat protein6e-0754.7