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Query: NC_008150:2207198:2220831 Yersinia pestis Antiqua, complete genome

Start: 2220831, End: 2221082, Length: 252

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1571305:160381516038151604066252Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-34144
NC_004088:1851500:188273418827341882985252Yersinia pestis KIM, complete genomehypothetical protein1e-34144
NC_008149:2337336:235096923509692351220252Yersinia pestis Nepal516, complete genomehypothetical protein1e-34144
NC_003143:2778494:278911627891162789367252Yersinia pestis CO92, complete genomehypothetical protein1e-34144
NC_010159:1794000:180315718031571803408252Yersinia pestis Angola, complete genome1e-34144
NC_009381:2138625:214132221413222141573252Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-34144
NC_017168:2941938:297306929730692973320252Yersinia pestis A1122 chromosome, complete genomehypothetical protein1e-34144
NC_010634:2894631:290007829000782900329252Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein1e-33141
NC_006155:2979500:298214829821482982399252Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-33141
NC_014306:2476316:24763162476316248644610131Erwinia billingiae Eb661, complete genomeContact-dependent inhibition of growth factor CdiA1e-1375.5
NC_005126:1265071:131188313118831312503621Photorhabdus luminescens subsp. laumondii TTO1, complete genomehypothetical protein1e-1272