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Query: NC_008150:2207198:2215656 Yersinia pestis Antiqua, complete genome

Start: 2215656, End: 2216186, Length: 531

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003143:2778494:278394127839412784486546Yersinia pestis CO92, complete genomehypothetical protein2e-100364
NC_005810:2549680:255356925535692554114546Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-100364
NC_004088:1851500:188761518876151888160546Yersinia pestis KIM, complete genomehypothetical protein2e-100364
NC_017265:1571305:160871116087111609241531Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein2e-100363
NC_009708:1735903:177207617720761772606531Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein2e-100363
NC_010634:2894631:289746328974632897993531Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein2e-100363
NC_010465:1790739:180670318067031807233531Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein2e-100363
NC_008149:2337336:234579423457942346324531Yersinia pestis Nepal516, complete genomehypothetical protein2e-100363
NC_006155:2979500:297953329795332980063531Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein2e-100363
NC_017168:2941938:297796529779652978492528Yersinia pestis A1122 chromosome, complete genomehypothetical protein2e-98357
NC_017160:2787637:282517928251792825631453Yersinia pestis D182038 chromosome, complete genomehypothetical protein2e-85314
NC_017154:2774955:278341327834132783865453Yersinia pestis D106004 chromosome, complete genomehypothetical protein2e-85314
NC_014029:2729832:273626327362632736715453Yersinia pestis Z176003 chromosome, complete genomehypothetical protein2e-85314
NC_010159:1794000:179797617979761798428453Yersinia pestis Angola, complete genomehypothetical protein2e-85314
NC_012491:4692667:471853247185324719200669Brevibacillus brevis NBRC 100599, complete genomehypothetical protein2e-1478.6
NC_005139:1784000:178729317872931787874582Vibrio vulnificus YJ016 chromosome I, complete sequencehypothetical protein2e-0858.9
NC_016641:5926000:594116959411695941768600Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein5e-0753.9
NC_020291:463500:468976468976469575600Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein6e-0650.4