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Query: NC_008150:2173708:2190581 Yersinia pestis Antiqua, complete genome

Start: 2190581, End: 2191084, Length: 504

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2999514:300315930031593003662504Yersinia pestis A1122 chromosome, complete genomehypothetical protein4e-85313
NC_003143:2741478:275877127587712759274504Yersinia pestis CO92, complete genomehypothetical protein4e-85313
NC_004088:1909880:191255719125571913060504Yersinia pestis KIM, complete genomehypothetical protein4e-85313
NC_005810:2508671:252869525286952529198504Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein4e-85313
NC_014471:217279:235811235811236320510Ignisphaera aggregans DSM 17230 chromosome, complete genomeformaldehyde-activating enzyme5e-22103
NC_007955:2074844:2095822209582220970121191Methanococcoides burtonii DSM 6242, complete genomeOrotidine 5'-phosphate decarboxylase2e-1995.1
NC_015574:2145000:214508421450842145575492Methanobacterium sp. SWAN-1 chromosome, complete genomeformaldehyde-activating enzyme1e-1789.4
NC_019977:253895:2548442548442560401197Methanomethylovorans hollandica DSM 15978, complete genomeformaldehyde-activating enzyme1e-1479
NC_014507:817977:8210308210308222261197Methanoplanus petrolearius DSM 11571 chromosome, complete genomeformaldehyde-activating enzyme1e-1479
NC_012968:1352463:135854713585471359110564Methylotenera mobilis JLW8, complete genomeformaldehyde-activating enzyme7e-1269.7
NC_012968:2228943:223859822385982239152555Methylotenera mobilis JLW8, complete genomeformaldehyde-activating enzyme4e-1167.4
NC_010524:3445641:345931734593173459862546Leptothrix cholodnii SP-6, complete genomeformaldehyde-activating enzyme2e-0961.6