Pre_GI: BLASTP Hits

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Query: NC_008150:2173708:2184833 Yersinia pestis Antiqua, complete genome

Start: 2184833, End: 2185510, Length: 678

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:2508671:252294725229472523645699Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-116417
NC_004088:1909880:191811019181101918808699Yersinia pestis KIM, complete genomehypothetical protein2e-116417
NC_003143:2741478:275302327530232753721699Yersinia pestis CO92, complete genomehypothetical protein2e-116417
NC_017168:2999514:300873330087333009410678Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-116417
NC_012917:2971702:298278429827842983716933Pectobacterium carotovorum subsp. carotovorum PC1, complete genomehypothetical protein1e-82306
NC_004547:1873390:193257519325751933540966Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein1e-80298
NC_013421:2004088:201290520129052013831927Pectobacterium wasabiae WPP163, complete genomeprotein of unknown function DUF6 transmembrane2e-79295
NC_012778:748143:765024765024765971948Eubacterium eligens ATCC 27750, complete genomehypothetical protein2e-34145
NC_013517:3846747:386155138615513862471921Sebaldella termitidis ATCC 33386, complete genomeprotein of unknown function DUF6 transmembrane1e-0860.1
NC_017208:256163:299415299415300335921Bacillus thuringiensis serovar chinensis CT-43 chromosome, completedrug/metabolite exporter family6e-0857.8
NC_014171:261952:309552309552310472921Bacillus thuringiensis BMB171 chromosome, complete genomedrug/metabolite exporter family protein5e-0754.7
NC_015856:4975815:499021449902144991116903Collimonas fungivorans Ter331 chromosome, complete genomehypothetical protein7e-0650.8