Pre_GI: BLASTP Hits

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Query: NC_008150:2173708:2184141 Yersinia pestis Antiqua, complete genome

Start: 2184141, End: 2184545, Length: 405

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:2508671:252225525222552522659405Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-64243
NC_004088:1909880:191909619190961919500405Yersinia pestis KIM, complete genomehypothetical protein2e-64243
NC_003143:2741478:275233127523312752693363Yersinia pestis CO92, complete genomehypothetical protein9e-56214
NC_017168:2999514:300993830099383010102165Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-1580.5