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Query: NC_008150:2173708:2183579 Yersinia pestis Antiqua, complete genome

Start: 2183579, End: 2183782, Length: 204

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2999514:3010461301046130115281068Yersinia pestis A1122 chromosome, complete genomeputative rhodanese-related sulfurtransferase9e-34142
NC_003143:2741478:2750905275090527519721068Yersinia pestis CO92, complete genomehypothetical protein9e-34142
NC_004088:1909880:1919805191980519209261122Yersinia pestis KIM, complete genomehypothetical protein1e-33141
NC_005810:2508671:2520829252082925219501122Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-33141
NC_020211:2012480:2017792201779220188591068Serratia marcescens WW4, complete genomeputative rhodanese-related sulfurtransferase4e-28123
NC_014306:1810548:1825626182562618266751050Erwinia billingiae Eb661, complete genomehypothetical protein9e-26115
NC_012912:1788308:1834173183417318352341062Dickeya zeae Ech1591, complete genomeRhodanese domain protein2e-25114
NC_015968:1709680:1730549173054917315981050Enterobacter asburiae LF7a chromosome, complete genomehypothetical protein8e-24108
NC_016510:1958453:1971686197168619730561371Flavobacterium columnare ATCC 49512 chromosome, complete genomerhodanese domain-containing protein4e-0856.6
NC_020156:1565500:1586108158610815871421035Nonlabens dokdonensis DSW-6, complete genomesulfurtransferase1e-0755.5