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Query: NC_008150:2173708:2177647 Yersinia pestis Antiqua, complete genome

Start: 2177647, End: 2178762, Length: 1116

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2999514:3014188301418830153031116Yersinia pestis A1122 chromosome, complete genomeN-methyltryptophan oxidase0726
NC_005810:2508671:2517054251705425181691116Yersinia pestis biovar Microtus str. 91001, complete genomeN-methyltryptophan oxidase0726
NC_003143:2741478:2747130274713027482451116Yersinia pestis CO92, complete genomeputative sarcosine oxidase0726
NC_004088:1909880:1923586192358619247011116Yersinia pestis KIM, complete genomesarcosine oxidase-like protein0724
NC_020211:2012480:2038214203821420393291116Serratia marcescens WW4, complete genomeFAD-binding N-methyltryptophan oxidase4e-145514
NC_007492:2629350:2635450263545026366101161Pseudomonas fluorescens PfO-1, complete genomeSarcosine oxidase2e-44179
NC_008148:792610:8041138041138053991287Rubrobacter xylanophilus DSM 9941, complete genomeSarcosine oxidase4e-44179
NC_014623:6509000:6511911651191165130321122Stigmatella aurantiaca DW4/3-1 chromosome, complete genomesarcosine oxidase5e-39162
NC_011887:110618:1196411196411207951155Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete1e-35150
NC_008148:1567703:1577597157759715787811185Rubrobacter xylanophilus DSM 9941, complete genomeSarcosine oxidase7e-31134
NC_002947:4293252:4303152430315243043001149Pseudomonas putida KT2440, complete genomesarcosine oxidase, putative6e-26118
NC_015410:3093465:3147996314799631491351140Pseudomonas mendocina NK-01 chromosome, complete genomeN-methyltryptophan oxidase8e-26118
NC_008009:5139896:5153936515393651550271092Acidobacteria bacterium Ellin345, complete genomeFAD dependent oxidoreductase2e-23110
NC_008319:262894:2794732794732806271155Synechococcus sp. CC9311, complete genomeputative sarcosine oxidase9e-1788.2
NC_014623:723089:7317827317827329931212Stigmatella aurantiaca DW4/3-1 chromosome, complete genomefad dependent oxidoreductase1e-1584.3
NC_013947:4363250:4377230437723043784111182Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeFAD dependent oxidoreductase3e-0653.1