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Query: NC_008150:2173708:2173708 Yersinia pestis Antiqua, complete genome

Start: 2173708, End: 2174754, Length: 1047

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010159:409500:4145684145684156141047Yersinia pestis Angola, complete genomedihydroorotase, homodimeric type0721
NC_004088:1909880:1927069192706919281151047Yersinia pestis KIM, complete genomedihydroorotase0721
NC_005810:2508671:2513116251311625141621047Yersinia pestis biovar Microtus str. 91001, complete genomedihydroorotase0721
NC_020211:2012480:2040649204064920416951047Serratia marcescens WW4, complete genomedihydro-orotase3e-178624
NC_012912:1788308:1837705183770518387481044Dickeya zeae Ech1591, complete genomedihydroorotase, homodimeric type1e-161569
NC_012779:2281700:2281700228170022827461047Edwardsiella ictaluri 93-146, complete genomedihydroorotase, homodimeric type, putative2e-145515
NC_007577:503440:5315695315695326181050Prochlorococcus marinus str. MIT 9312, complete genomedihydroorotase, homodimeric type6e-103374
NC_008786:1332041:1350163135016313512061044Verminephrobacter eiseniae EF01-2, complete genomedihydroorotase, homodimeric type2e-99362
NC_015942:447308:458213458213458758546Acidithiobacillus ferrivorans SS3 chromosome, complete genomehypothetical protein5e-21102