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Query: NC_008149:2366500 Yersinia pestis Nepal516, complete genome

Start: 2366500, End: 2384099, Length: 17600

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003143:28045002804500282209917600Yersinia pestis CO92, complete genome016720BLASTN svgBLASTP svg
NC_010159:18185001818500183609917600Yersinia pestis Angola, complete genome016710BLASTN svgBLASTP svg
NC_005810:25496802549680258809938420Yersinia pestis biovar Microtus str. 91001, complete genome016710BLASTN svgBLASTP svg
NC_004088:1851500*1851500188954638047Yersinia pestis KIM, complete genome016710BLASTN svgBLASTP svg
NC_010634:28946312894631293584741217Yersinia pseudotuberculosis PB1/+, complete genome011500BLASTN svgBLASTP svg
NC_006155:29795002979500301649636997Yersinia pseudotuberculosis IP 32953, complete genome011480BLASTN svgBLASTP svg
NC_020211:35356223535622355884723226Serratia marcescens WW4, complete genome5e-75289BLASTN svgBLASTP svg
AP010958:92293792293795098628050Escherichia coli O103:H2 str. 12009 DNA, complete genome2e-21111BLASTN svgBLASTP svg
CP002797:47757804775780479609920320Escherichia coli NA114, complete genome6e-1693.7BLASTN svgBLASTP svg
NC_015061:1481500*1481500150744925950Rahnella sp. Y9602 chromosome, complete genome2e-1591.7BLASTN svgBLASTP svg
NC_013421:3117639*3117639314038322745Pectobacterium wasabiae WPP163, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_006582:883922*88392291459930678Bacillus clausii KSM-K16, complete genome2e-0661.9BLASTN svgBLASTP svg