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Query: NC_008149:3790897:3801574 Yersinia pestis Nepal516, complete genome

Start: 3801574, End: 3802608, Length: 1035

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:515744:5240515240515251391089Yersinia pestis biovar Microtus str. 91001, complete genomerhamnose-proton symporter2e-180631
NC_006155:456000:4645764645764656101035Yersinia pseudotuberculosis IP 32953, complete genomeL-rhamnose-proton symporter3e-180630
NC_010465:4222586:4230513423051342315471035Yersinia pseudotuberculosis YPIII, complete genomeL-rhamnose-proton symporter, RhaT family, DMT superfamily3e-180630
NC_010159:741819:7510127510127520461035Yersinia pestis Angola, complete genomeL-rhamnose-proton symporter3e-180630
NC_009381:4169353:4180006418000641810401035Yersinia pestis Pestoides F chromosome, complete genomerhamnose-proton symporter3e-180630
NC_009708:4215500:4226621422662142276551035Yersinia pseudotuberculosis IP 31758 chromosome, complete genomerhamnose-proton symporter3e-180630
NC_014029:331919:3394113394113404451035Yersinia pestis Z176003 chromosome, complete genomeL-rhamnose-proton symporter3e-180630
NC_017154:331921:3394143394143404481035Yersinia pestis D106004 chromosome, complete genomeL-rhamnose-proton symporter3e-180630
NC_017168:751078:7617557617557627891035Yersinia pestis A1122 chromosome, complete genomerhamnose-proton symporter3e-180630
NC_017265:644384:6528916528916539251035Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,L-rhamnose-proton symporter1e-179629
NC_013421:553193:5572515572515582851035Pectobacterium wasabiae WPP163, complete genomeL-rhamnose-proton symporter, RhaT family, DMT superfamily6e-146517