Pre_GI: BLASTP Hits

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Query: NC_008149:3790897:3801154 Yersinia pestis Nepal516, complete genome

Start: 3801154, End: 3801420, Length: 267

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:644384:652471652471652737267Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-43174
NC_005810:515744:525239525239525505267Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-43174
NC_010465:4222586:423009342300934230359267Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein1e-43174
NC_006155:456000:465764465764466054291Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-41168
NC_009381:4169353:417961041796104179852243Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein3e-37153