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Query: NC_008149:3790897:3797311 Yersinia pestis Nepal516, complete genome

Start: 3797311, End: 3799866, Length: 2556

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:644384:6486286486286511832556Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Enhancing factor01654
NC_017168:751078:7574927574927600472556Yersinia pestis A1122 chromosome, complete genomeenhancing factor01654
NC_017154:331921:3421563421563447112556Yersinia pestis D106004 chromosome, complete genomeenhancing factor01654
NC_014029:331919:3421533421533447082556Yersinia pestis Z176003 chromosome, complete genomeenhancing factor01654
NC_010159:741819:7460637460637486182556Yersinia pestis Angola, complete genomeviral enhancin protein01654
NC_009381:4169353:4175767417576741783222556Yersinia pestis Pestoides F chromosome, complete genomeenhancing factor01653
NC_005810:515744:5267785267785293482571Yersinia pestis biovar Microtus str. 91001, complete genomeenhancing factor01652
NC_010465:4222586:4226250422625042288052556Yersinia pseudotuberculosis YPIII, complete genomepeptidase M60 viral enhancin protein01648
NC_009708:4215500:4222334422233442249042571Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeviral enhancin protein01643
NC_006155:456000:4673274673274698972571Yersinia pseudotuberculosis IP 32953, complete genomeenhancing factor (viral)01641
NC_012563:2384500:2384727238472723875042778Clostridium botulinum A2 str. Kyoto, complete genomeviral enhancin protein5e-126452
NC_012658:2295536:2298839229883923016162778Clostridium botulinum Ba4 str. 657 chromosome, complete genomeenhancing factor3e-125449
NC_009699:2287893:2290364229036422931412778Clostridium botulinum F str. Langeland chromosome, complete genomeenhancing factor3e-123443
NC_007103:131000:1471681471681488141647Bacillus cereus E33L plasmid pE33L466, complete sequenceenhancin family protein8e-63242
NC_017297:2288000:229289122928912293253363Clostridium botulinum F str. 230613 chromosome, complete genome5e-0757.4