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Query: NC_008149:3251196:3273690 Yersinia pestis Nepal516, complete genome

Start: 3273690, End: 3273766, Length: 77

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009381:1783886:18263561826356182643277Yersinia pestis Pestoides F chromosome, complete genometRNA-Asp7e-0752.8
NC_004088:3382148:34046263404626340469974Yersinia pestis KIM, complete genometRNA-Asp3e-0650.8
CP002516:3863932:38824283882428388250477Escherichia coli KO11, complete genometRNA-Asp5e-0650.1
NC_009648:4656187:46685724668572466864877Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genometRNA-Asp5e-0650.1
CP002516:3863932:38742043874204387428077Escherichia coli KO11, complete genometRNA-Asp5e-0650.1
CP002185:234719:23762323762323769977Escherichia coli W, complete genometRNA-Asp5e-0650.1
NC_016822:246715:24961924961924969577Shigella sonnei 53G, complete genometRNA-Asp5e-0650.1
NC_016902:3863932:38742043874204387428077Escherichia coli KO11FL chromosome, complete genometRNA-Asp5e-0650.1
NC_016902:3863932:38824283882428388250477Escherichia coli KO11FL chromosome, complete genometRNA-Asp5e-0650.1
NC_007645:2204066:22157182215718221579477Hahella chejuensis KCTC 2396, complete genometRNA-Asp6e-0649.7