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Query: NC_008149:3251196:3271577 Yersinia pestis Nepal516, complete genome

Start: 3271577, End: 3271810, Length: 234

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004088:3382148:340252834025283402767240Yersinia pestis KIM, complete genomehypothetical protein4e-39159
NC_009381:1783886:182352618235261824476951Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein6e-37152
NC_016514:1627664:165020416502041651142939Enterobacter cloacae EcWSU1 chromosome, complete genomepolysaccharide Deacetylase3e-27120
NC_013850:2624899:262801226280122628944933Klebsiella variicola At-22 chromosome, complete genomeurate catabolism protein2e-25114
NC_011283:2627050:263016326301632631095933Klebsiella pneumoniae 342 chromosome, complete genomeurate catabolism protein2e-25114
NC_012731:2693091:270320627032062704138933Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeputative polysaccharide deacetylase5e-25112
NC_009648:1956070:196958619695861970518933Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeputative polysaccharide deacetylase6e-25112
NC_010002:2293670:231604723160472317003957Delftia acidovorans SPH-1, complete genomeurate catabolism protein2e-21100
NC_010995:671389:688838688838689734897Cellvibrio japonicus Ueda107, complete genomepolysaccharide deacetylase protein, putative, pda4B9e-2095.5
NC_012997:2059092:209738120973812098364984Teredinibacter turnerae T7901, complete genomecarbohydrate esterase family 4 domain protein1e-1995.1
NC_012691:2146473:215020721502072151130924Tolumonas auensis DSM 9187, complete genomeurate catabolism protein1e-1891.7
NC_008043:499399:4993994993995008141416Silicibacter sp. TM1040 mega plasmid, complete sequencepolysaccharide deacetylase1e-1685.1
NC_017192:1063955:106999310699931070919927Arcobacter sp. L, complete genomeputative polysaccharide deacetylase5e-1683.2
NC_016845:2729654:274534927453492746188840Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,urate catabolism protein2e-1374.3