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Query: NC_008149:3251196:3260469 Yersinia pestis Nepal516, complete genome

Start: 3260469, End: 3261557, Length: 1089

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1136000:1143647114364711447351089Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein0733
NC_005810:1130251:1139524113952411406121089Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein0733
NC_003143:1233128:1242317124231712434051089Yersinia pestis CO92, complete genomehypothetical protein0733
NC_004088:3382148:3391421339142133925091089Yersinia pestis KIM, complete genomehypothetical protein0733
NC_008150:650899:6590536590536601411089Yersinia pestis Antiqua, complete genomehypothetical protein0733
NC_010159:1417993:1426469142646914275571089Yersinia pestis Angola, complete genomehypothetical protein0733
NC_009381:2939782:2949055294905529501431089Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein0733
NC_014029:1283500:1291514129151412926021089Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0733
NC_017154:1225500:1233607123360712346951089Yersinia pestis D106004 chromosome, complete genomehypothetical protein0733
NC_017160:1507500:1516916151691615180041089Yersinia pestis D182038 chromosome, complete genomehypothetical protein0733
NC_017168:4155143:4164333416433341654211089Yersinia pestis A1122 chromosome, complete genomehypothetical protein0733
NC_007912:529500:5475415475415486321092Saccharophagus degradans 2-40, complete genomehypothetical protein2e-42173
NC_008060:3155133:3168493316849331696021110Burkholderia cenocepacia AU 1054 chromosome 1, complete sequencehypothetical protein8e-39161
NC_015167:1911758:1925795192579519268651071Cellulophaga lytica DSM 7489 chromosome, complete genomehypothetical protein3e-35149
NC_013132:4355363:4372112437211243732241113Chitinophaga pinensis DSM 2588, complete genomehypothetical protein3e-1686.3