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Query: NC_008149:2517538:2529031 Yersinia pestis Nepal516, complete genome

Start: 2529031, End: 2529303, Length: 273

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:2306500:231405023140502314322273Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-46184
NC_017168:3535786:353810735381073538379273Yersinia pestis A1122 chromosome, complete genomehypothetical protein1e-46184
NC_004088:2691565:269388626938862694158273Yersinia pestis KIM, complete genomehypothetical protein1e-46184
NC_005810:1663672:166633116663311666603273Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-46184
NC_015224:2095816:209556320955632095835273Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein9e-46181
NC_017267:2698944:271519627151962715477282Xanthomonas oryzae pv. oryzicola BLS256 chromosome, completepANL568e-25112
NC_012751:942315:942315942315942593279Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum), completehypothetical protein1e-1892
NC_010645:1496816:151532915153291515595267Bordetella avium 197N, complete genomephage protein5e-1786.3
NC_004556:1178897:120040612004061200672267Xylella fastidiosa Temecula1, complete genomehypothetical protein1e-1685.1
NC_010577:1188438:120994612099461210212267Xylella fastidiosa M23, complete genomeprotein of unknown function DUF4971e-1685.1
NC_007650:1192310:121619712161971216466270Burkholderia thailandensis E264 chromosome II, complete sequencepANL568e-1682.4
NC_014972:210500:211140211140211412273Desulfobulbus propionicus DSM 2032 chromosome, complete genomehypothetical protein2e-1064.7
NC_017033:1052000:106136310613631061506144Frateuria aurantia DSM 6220 chromosome, complete genome1e-0962
NC_007494:739403:743884743884744174291Rhodobacter sphaeroides 2.4.1 chromosome 2, complete sequencehypothetical protein1e-0858.5
NC_014355:2321957:232371623237162324006291Candidatus Nitrospira defluvii, complete genomehypothetical protein3e-0753.9
NC_006351:520500:539482539482539703222Burkholderia pseudomallei K96243 chromosome 2, complete sequencehypothetical protein3e-0753.9
NC_009078:510525:523248523248523469222Burkholderia pseudomallei 1106a chromosome II, complete sequencehypothetical protein3e-0753.9
NC_015222:1905194:191853319185331918808276Nitrosomonas sp. AL212 chromosome, complete genomehypothetical protein5e-0753.1
NC_004129:195347:209336209336209620285Pseudomonas fluorescens Pf-5, complete genomeProtein of unknown function (DUF497) superfamily4e-0650.4
NC_007490:76838:921389213892410273Rhodobacter sphaeroides 2.4.1 plasmid D, complete sequencehypothetical protein4e-0650.1