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Query: NC_008149:1221637:1240024 Yersinia pestis Nepal516, complete genome

Start: 1240024, End: 1240878, Length: 855

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003143:2895617:291397229139722914937966Yersinia pestis CO92, complete genomehypothetical protein3e-149527
NC_004088:1291754:131012313101231311088966Yersinia pestis KIM, complete genomehypothetical protein3e-149527
NC_008150:2785830:279605327960532796907855Yersinia pestis Antiqua, complete genomehypothetical protein5e-149526
NC_017154:3094000:3095062309506230960991038Yersinia pestis D106004 chromosome, complete genomehypothetical protein2e-147521
NC_008800:3279468:328488332848833285848966Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein2e-140498
NC_015224:1440283:145212714521271453092966Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein2e-140498
NC_016612:5231065:523412452341245235089966Klebsiella oxytoca KCTC 1686 chromosome, complete genomehypothetical protein1e-27123
NC_016612:5208936:523412452341245235089966Klebsiella oxytoca KCTC 1686 chromosome, complete genomehypothetical protein1e-27123
NC_015061:3840463:391367439136743914639966Rahnella sp. Y9602 chromosome, complete genomehypothetical protein1e-25117
NC_014033:1808782:1828716182871618297191004Prevotella ruminicola 23 chromosome, complete genome3e-0652.8