Pre_GI: BLASTP Hits

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Query: NC_007797:1016456:1034810 Anaplasma phagocytophilum HZ, complete genome

Start: 1034810, End: 1035583, Length: 774

Host Lineage: Anaplasma phagocytophilum; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013009:562470:593773593773594537765Neorickettsia risticii str. Illinois, complete genomeacetyltransferase, gnat family9e-37153