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Query: NC_007606:1209132:1223820 Shigella dysenteriae Sd197, complete genome

Start: 1223820, End: 1224329, Length: 510

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013008:1761165:178172817817281782234507Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehypothetical protein1e-92338
NC_011353:1761977:178275217827521783258507Escherichia coli O157:H7 str. EC4115 chromosome, complete genomehypothetical protein1e-92338
NC_002695:1794635:181573818157381816244507Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein1e-92338
NC_002655:2264773:227093322709332271439507Escherichia coli O157:H7 EDL933, complete genomehypothetical protein1e-92338
NC_013361:1754346:177486717748671775373507Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein4e-92336
NC_013353:1472506:149161314916131492119507Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein2e-91334
AP010958:1472506:149161314916131492119507Escherichia coli O103:H2 str. 12009 DNA, complete genomeconserved predicted protein2e-91334
NC_013941:1613595:162781916278191628325507Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeYciE protein2e-91334
NC_010473:1384000:140213814021381402644507Escherichia coli str. K-12 substr. DH10B, complete genomehypothetical protein2e-91333
NC_011283:3379181:338154733815473382053507Klebsiella pneumoniae 342 chromosome, complete genomehypothetical protein2e-82304
NC_015410:2698572:270341827034182703927510Pseudomonas mendocina NK-01 chromosome, complete genomehypothetical protein3e-42171
NC_007964:4157500:417410041741004174603504Nitrobacter hamburgensis X14, complete genomeprotein of unknown function DUF8921e-35149
NC_010170:1661915:168258916825891683110522Bordetella petrii, complete genomehypothetical protein6e-34143
NC_008343:88184:100365100365100880516Granulibacter bethesdensis CGDNIH1, complete genomehypothetical protein1e-21102
NC_010725:4035397:404295140429514043463513Methylobacterium populi BJ001, complete genomeprotein of unknown function DUF8923e-1064.3
NC_010170:3944228:398631539863153986530216Bordetella petrii, complete genomehypothetical protein5e-0857