Pre_GI: BLASTP Hits

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Query: NC_007530:5006319:5015902 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 5015902, End: 5016606, Length: 705

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:5006219:501580250158025016506705Bacillus anthracis str. A0248, complete genomeputative ABC transporter, permease protein2e-130464
NC_012581:5008749:501833250183325019036705Bacillus anthracis str. CDC 684 chromosome, complete genomeABC transporter permease2e-130464
NC_003997:5006193:501577650157765016480705Bacillus anthracis str. Ames, complete genomeABC transporter, permease protein, putative2e-130464
NC_005945:5011857:501711150171115017815705Bacillus anthracis str. Sterne, complete genomeABC transporter, permease protein, putative2e-130464
NC_011969:4993386:499338649933864994090705Bacillus cereus Q1 chromosome, complete genomeABC transporter permease5e-128456
NC_011658:5049349:504934950493495050053705Bacillus cereus AH187 chromosome, complete genomeputative ABC transporter permease5e-128456
NC_004722:5194000:519404751940475194751705Bacillus cereus ATCC 14579, complete genomeABC transporter permease protein2e-104378
NC_011725:5201995:520199552019955202699705Bacillus cereus B4264 chromosome, complete genomeABC transporter permease2e-104378
NC_009674:3863667:386296338629633863670708Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeABC-2 type transporter5e-54211
NC_012673:2064298:208169720816972082404708Exiguobacterium sp. AT1b, complete genomeABC-2 type transporter1e-31136
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome1e-25116
NC_004193:375416:507140507140507841702Oceanobacillus iheyensis HTE831, complete genomehypothetical protein3e-22105