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Query: NC_007530:5006319:5006319 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 5006319, End: 5008883, Length: 2565

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:5006219:5006219500621950087862568Bacillus anthracis str. A0248, complete genomehypothetical protein01759
NC_012581:5008749:5008749500874950113162568Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein01759
NC_003997:5006193:5006193500619350087572565Bacillus anthracis str. Ames, complete genomehypothetical protein01758
NC_010322:1520973:1555924155592415622626339Pseudomonas putida GB-1 chromosome, complete genometype 12 methyltransferase3e-95350
NC_016048:3667890:3694882369488236965611680Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-95349
NC_013960:379461:3794613794613845155055Nitrosococcus halophilus Nc4 chromosome, complete genomemethyltransferase FkbM family6e-85316
NC_013172:3093467:3108786310878631107111926Brachybacterium faecium DSM 4810, complete genomehypothetical protein2e-67258
NC_014830:1252249:1256833125683312587251893Intrasporangium calvum DSM 43043 chromosome, complete genomeglycosyl transferase family 25e-65249
NC_014550:1581812:1605868160586816076101743Arthrobacter arilaitensis Re117, complete genomeputative glycosyl transferase9e-63242
NC_009342:464210:4851134851134887963684Corynebacterium glutamicum R chromosome, complete genomehypothetical protein2e-62241
NC_010617:1397274:1401039140103914029551917Kocuria rhizophila DC2201, complete genomehypothetical protein2e-61237
NC_014830:1252249:1270112127011212740623951Intrasporangium calvum DSM 43043 chromosome, complete genomeglycosyl transferase group 15e-60233
NC_015696:798000:800067800067801062996Francisella sp. TX077308 chromosome, complete genomeputative spore protein2e-50201
NC_010336:1282265:128520312852031286198996Francisella philomiragia subsp. philomiragia ATCC 25017, completeputative spore protein5e-48193
NC_010617:1397274:1404926140492614075922667Kocuria rhizophila DC2201, complete genomeputative glycosyltransferase8e-27122
NC_013406:1707570:1726422172642217275401119Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein4e-1067.8
NC_008312:2264832:2264832226483222700455214Trichodesmium erythraeum IMS101, complete genomeglycosyl transferase, family 23e-0758.2