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Query: NC_007530:4176462:4197790 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 4197790, End: 4197978, Length: 189

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4191963:420856742085674208755189Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-2097.4
NC_011969:4065460:408392940839294084117189Bacillus cereus Q1 chromosome, complete genomehypothetical protein2e-2097.4
NC_011658:4171237:418856941885694188757189Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-2097.4
NC_005957:4169610:418694941869494187137189Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-2097.4
NC_011772:4321117:433581943358194336007189Bacillus cereus G9842, complete genomehypothetical protein2e-2097.4
NC_014335:4113154:412949641294964129684189Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein3e-2097.1
NC_010184:4219257:423424142342414234429189Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein9e-2095.5
NC_014377:1089894:110667811066781106848171Thermosediminibacter oceani DSM 16646 chromosome, complete genomehypothetical protein6e-0649.7